Evidence map›Paper›PMID 33483500›Full record

ArticleNature communications2021

Structural basis of ribosomal RNA transcription regulation.

Yeonoh Shin, M Zuhaib Qayyum, Danil Pupov, Daria Esyunina, Andrey Kulbachinskiy, Katsuhiko S Murakami

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 67 citations in OpenAlex.

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  15. Determinants ofGenes · 2024
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  18. Structure and function of the Si3 insertion integrated into the trigger loop/helix of cyanobacterial RNA polymerase.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yeonoh Shin *Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, 16802, USA.ORCID http://orcid.org/0000-0001-9718-2995
M Zuhaib Qayyum *Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, 16802, USA.
Danil PupovInstitute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia.ORCID http://orcid.org/0000-0003-4961-6888
Daria EsyuninaInstitute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia.
Andrey KulbachinskiyInstitute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia.ORCID http://orcid.org/0000-0002-2292-6424
Katsuhiko S MurakamiDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, 16802, USA. kum14@psu.edu.ORCID http://orcid.org/0000-0003-2244-0501
Institute of Molecular Genetics · RUPennsylvania State University · US

Funding

X-Ray Crystallographic Studies of Multi-Subunit Nucleic Acid PolymerasesR01GM087350 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MURAKAMI, KATSUHIKO · 2010 to 2018
$2.6M
Structural study of direct associations between cellular RNA polymerase and regulatory factors during the transcription cycleR35GM131860 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MURAKAMI, KATSUHIKO · 2019 to 2023
$2.2M
NIGMS NIH HHS R01 GM087350NIGMS NIH HHS R35 GM131860
6 · The paper itself

Abstract

Ribosomal RNA (rRNA) is most highly expressed in rapidly growing bacteria and is drastically downregulated under stress conditions by the global transcriptional regulator DksA and the alarmone ppGpp. Here, we determined cryo-electron microscopy structures of the Escherichia coli RNA polymerase (RNAP) σ

Indexed as

Gene Expression Regulation, BacterialTranscription, GeneticCryoelectron MicroscopyDNA, BacterialDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsGuanosine TetraphosphateHoloenzymesPromoter Regions, GeneticProtein ConformationRNA, BacterialRNA, RibosomalSigma FactorTranscription Initiation SitedksA protein, E coliDNA, BacterialDNA-Directed RNA PolymerasesEscherichia coli ProteinsGuanosine TetraphosphateHoloenzymesRNA, BacterialRNA polymerase sigma 70RNA, RibosomalSigma Factor

Identifiers

PMID33483500
PMCPMC7822876
OpenAlexW3123789517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.