ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Neurobiological mechanisms of olfactory dysfunction: a ten-year bibliometric and visualization analysis.Frontiers in medicine · 2026Pooled it
- Abl kinase activation promotes axon initial segment disassembly and protein sorting defects in Alzheimer's disease.BMC biology · 2026Article
- Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Conflicting adaptations in an inhibitory feedback circuit.The Journal of physiology · 2026Article
- Deletion of the calcium-binding protein S100β alters axon initial segment development in the visual cortex.Frontiers in cellular neuroscience · 2026Article
- Article
- Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dopaminergic short axon cells integrate sensory and top-down inputs to enhance discriminative learning in the mouse olfactory bulb.PLoS biology · 2025Article
- Interactions between homeostatic plasticity and statistical learning: A role for inhibition.Current opinion in neurobiology · 2025Review
- Functional Maturation and Experience-Dependent Plasticity in Adult-Born Olfactory Bulb Dopaminergic Neurons.The European journal of neuroscience · 2025Article
- Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model.Journal of neuroinflammation · 2025Article
- Ex Vivo Functional Characterization of Mouse Olfactory Bulb Projection Neurons Reveals a Heterogeneous Continuum.eNeuro · 2025Article
- Amplification of olfactory transduction currents implements sparse stimulus encoding.bioRxiv : the preprint server for biology · 2024Article
- Cell type- and layer-specific plasticity of olfactory bulb interneurons following olfactory sensory neuron ablation.Scientific reports · 2024Article
- Intrinsic Plasticity Mechanisms of Repetitive Transcranial Magnetic Stimulation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Deprivation-Induced Plasticity in the Early Central Circuits of the Rodent Visual, Auditory, and Olfactory Systems.eNeuro · 2024Review
- Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons.Cell reports · 2023Article
- Sensory deprivation arrests cellular and synaptic development of the night-vision circuitry in the retina.Current biology : CB · 2023Article
- Sodium channel endocytosis drives axon initial segment plasticity.Science advances · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Can alterations in experience trigger different plastic modifications in neuronal structure and function, and if so, how do they integrate at the cellular level? To address this question, we interrogated circuitry in the mouse olfactory bulb responsible for the earliest steps in odor processing. We induced experience-dependent plasticity in mice of either sex by blocking one nostril for one day, a minimally invasive manipulation that leaves the sensory organ undamaged and is akin to the natural transient blockage suffered during common mild rhinal infections. We found that such brief sensory deprivation produced structural and functional plasticity in one highly specialized bulbar cell type: axon-bearing dopaminergic neurons in the glomerular layer. After 24 h naris occlusion, the axon initial segment (AIS) in bulbar dopaminergic neurons became significantly shorter, a structural modification that was also associated with a decrease in intrinsic excitability. These effects were specific to the AIS-positive dopaminergic subpopulation because no experience-dependent alterations in intrinsic excitability were observed in AIS-negative dopaminergic cells. Moreover, 24 h naris occlusion produced no structural changes at the AIS of bulbar excitatory neurons, mitral/tufted and external tufted cells, nor did it alter their intrinsic excitability. By targeting excitability in one specialized dopaminergic subpopulation, experience-dependent plasticity in early olfactory networks might act to fine-tune sensory processing in the face of continually fluctuating inputs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.