ArticleProceedings of the National Academy of Sciences of the United States of America2021
The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Roles for specialized secretory epithelial cells in inflammatory bowel disease.Current opinion in gastroenterology · 2026Review
- DHX15 overexpression suppresses colorectal cancer cell line proliferation.Oncology letters · 2026Article
- Aged garlic extract enhances the production of β‑defensin 4 via activation of the Wnt/β‑catenin pathway in mouse gingiva.Experimental and therapeutic medicine · 2025Article
- Blockade of PI3K/AKT signaling pathway by Astragaloside IV attenuates ulcerative colitis via improving the intestinal epithelial barrier.Journal of translational medicine · 2024Article
- DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells.Nature communications · 2024Article
- Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.International journal of molecular sciences · 2024Article
- Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.Nature communications · 2024Article
- A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival.iScience · 2024Article
- Multifaceted involvements of Paneth cells in various diseases within intestine and systemically.Frontiers in immunology · 2023Review
- Paneth cell development in the neonatal gut: pathway regulation, development, and relevance to necrotizing enterocolitis.Frontiers in cell and developmental biology · 2023Review
- The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions.Cellular & molecular immunology · 2022Article
- Overview of Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine and Immune System and Their Role in Inflammatory Bowel Diseases (IBDs).Frontiers in medicine · 2022Review
- Molecular regulation after mucosal injury and regeneration in ulcerative colitis.Frontiers in molecular biosciences · 2022Review
- Crosstalk Between the Gut Microbiota and Epithelial Cells Under Physiological and Infectious Conditions.Frontiers in cellular and infection microbiology · 2022Review
- DDX3 acts as a tumor suppressor in colorectal cancer as loss of DDX3 in advanced cancer promotes tumor progression by activating the MAPK pathway.International journal of biological sciences · 2022Article
- Host-Viral Interactions in the Pathogenesis of Ulcerative Colitis.International journal of molecular sciences · 2021Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
22 authors at 8 institutions in 2 countries.
Yalong WangDepartment of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, China.ORCID https://orcid.org/0000-0002-9557-9101
Kaixin HeDepartment of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, China.
Baifa ShengDepartment of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, China.ORCID https://orcid.org/0000-0001-8137-6154
Xuqiu LeiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520.ORCID https://orcid.org/0000-0003-3565-6969
Wanyin TaoHefei National Laboratory for Physical Sciences at Microscale, the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027 Hefei, China.
Xiaoliang ZhuThe State Key Laboratory of Molecular Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Networks, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Zheng WeiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520.ORCID https://orcid.org/0000-0002-1859-0374
Rongjie FuThe State Key Laboratory of Molecular Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Networks, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Anlei WangHefei National Laboratory for Physical Sciences at Microscale, the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027 Hefei, China.ORCID https://orcid.org/0000-0003-0590-1804
Shengdan BaiHefei National Laboratory for Physical Sciences at Microscale, the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027 Hefei, China.
Zhao ZhangHefei National Laboratory for Physical Sciences at Microscale, the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027 Hefei, China.ORCID https://orcid.org/0000-0001-7610-6774
Na HongDepartment of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, China.
Chao YeDepartment of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, China.
Ye TianState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.ORCID https://orcid.org/0000-0002-7675-9270
Jun WangDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016.ORCID https://orcid.org/0000-0002-6346-2929
Mingsong LiDigestive Department, The Third Affiliated Hospital of Guangzhou Medical University, 510150 Guangzhou, China.
Kaiguang ZhangDepartment of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, China.
Lin LiThe State Key Laboratory of Molecular Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Networks, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Hua YangDepartment of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, China; hwbyang@126.com huabing.li@shsmu.edu.cn richard.flavell@yale.edu zhushu@ustc.edu.cn.
Hua-Bing LiShanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; hwbyang@126.com huabing.li@shsmu.edu.cn richard.flavell@yale.edu zhushu@ustc.edu.cn.ORCID https://orcid.org/0000-0003-3573-6803
Richard A FlavellDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; hwbyang@126.com huabing.li@shsmu.edu.cn richard.flavell@yale.edu zhushu@ustc.edu.cn.
Shu ZhuDepartment of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, China; hwbyang@126.com huabing.li@shsmu.edu.cn richard.flavell@yale.edu zhushu@ustc.edu.cn.ORCID https://orcid.org/0000-0002-8163-0869
University of Science and Technology of China · CNChinese Academy of Sciences · CNArmy Medical University · CNYale University · USHoward Hughes Medical Institute · USNYU Langone Health · USShanghai Jiao Tong University · CNThird Affiliated Hospital of Guangzhou Medical University · CN
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MSystems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI David A. Hafler, RUTH R MONTGOMERY · 2010 to 2026
$50.4MThe role of NLRP6 and DHX15 in control of infection by RNA virusesR01AI127865 · NIAID · YALE UNIVERSITY · PI FIKRIG, EROL, FLAVELL, RICHARD A · 2018 to 2022
$2.1MHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI127865NIAID NIH HHS U19 AI089992
Abstract
RNA helicases play roles in various essential biological processes such as RNA splicing and editing. Recent in vitro studies show that RNA helicases are involved in immune responses toward viruses, serving as viral RNA sensors or immune signaling adaptors. However, there is still a lack of in vivo data to support the tissue- or cell-specific function of RNA helicases owing to the lethality of mice with complete knockout of RNA helicases; further, there is a lack of evidence about the antibacterial role of helicases. Here, we investigated the in vivo role of Dhx15 in intestinal antibacterial responses by generating mice that were intestinal epithelial cell (IEC)-specific deficient for Dhx15 (Dhx15 f/f Villin1-cre, Dhx15
Indexed as
Wnt Signaling PathwayAnimalsCitrobacter rodentiumColitisDefensinsDextran SulfateEnterobacteriaceae InfectionsGastrointestinal MicrobiomeGene Expression RegulationHumansMiceMice, TransgenicMicrofilament ProteinsPaneth CellsProtein IsoformsRNA HelicasesDefensinsDextran SulfateDhx15 protein, mouseMicrofilament ProteinsProtein IsoformsRNA HelicasesVil1 protein, mousealpha-defensinsDEAD-box helicase 15 (Dhx15)inflammatory bowel diseases (IBD)intestinal inflammationPaneth cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.