Evidence map›Paper›PMID 33483333›Full record

ArticleImmunoHorizons2021

Regulatory T Cell-Derived TRAIL Is Not Required for Peripheral Tolerance.

Rebekah E Dadey, Stephanie Grebinoski, Qianxia Zhang, Erin A Brunazzi, Amanda Burton, Creg J Workman, Dario A A Vignali

Open access · goldAbstract read
In one paragraph

Article in ImmunoHorizons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rebekah E DadeyDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Stephanie GrebinoskiDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.ORCID 0000-0002-3562-3190
Qianxia ZhangDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.ORCID 0000-0002-2885-2147
Erin A BrunazziDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Amanda BurtonDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105; and.
Creg J WorkmanDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Dario A A VignaliDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; dvignali@pitt.edu.ORCID 0000-0002-2771-5992
University of Pittsburgh · USSt. Jude Children's Research Hospital · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
WILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 2004 to 2026
$49.6M
Synergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI E. John Wherry · 2015 to 2026
$30.8M
TIM recognition of phosphatidylserine regulates innate and adaptive immunityP01AI054456 · NIAID · STANFORD UNIVERSITY · PI FREEMAN, GORDON JAMES · 2003 to 2014
$12.8M
Training in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2M
Interleukin-35 and the tumor microenvironmentR01CA203689 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VIGNALI, DARIO AA · 2016 to 2020
$1.9M
Special BD LSRFortessaTMS10OD011925 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BORGHESI, LISA · 2012 to 2012
$383k
IFN-y drives Treg fragility through DNA methylation of the Treg-specific de-methylated regionsF31CA236337 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DADEY, REBEKAH · 2019 to 2020
$91k
NCI NIH HHS F31 CA236337NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA097190NCI NIH HHS R01 CA203689NCI NIH HHS T32 CA082084NIAID NIH HHS P01 AI054456NIAID NIH HHS P01 AI108545NIH HHS S10 OD011925
6 · The paper itself

Abstract

TRAIL (

Indexed as

Peripheral ToleranceAnimalsApoptosisDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleFlow CytometryLymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NODMice, KnockoutMyelin-Oligodendrocyte GlycoproteinNeoplasmsMyelin-Oligodendrocyte GlycoproteinTNF-Related Apoptosis-Inducing LigandTnfsf10 protein, mouse

Identifiers

PMID33483333
PMCPMC8663370
OpenAlexW3123407884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.