SynthesisBehavior therapy2021
The Effect of Concurrent Depression on PTSD Outcomes in Trauma-Focused Psychotherapy: A Meta-Analysis of Randomized Controlled Trials.
Synthesis in Behavior therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- How is trauma-focused therapy experienced by adults with PTSD? A systematic review of qualitative studies.BMC psychology · 2024Pooled it
- Depressive symptoms are a key determinant of health-related quality of life in ICU survivors with psychological distress.Scientific reports · 2026Trial
- A Randomized Controlled Trial Comparing Group Transdiagnostic Behavior Therapy (TBT) and Group Disorder-Specific Psychotherapies in Veterans With Emotional Disorders.Journal of clinical psychology · 2026Trial
- Sex differences in treatment outcomes among U.S. service members with comorbid PTSD and MDD.BMC psychology · 2026Trial
- Comorbidity as a moderator of the differential efficacy of transdiagnostic behavior therapy and behavioral activation for affective disorders.Psychotherapy research : journal of the Society for Psychotherapy Research · 2022Trial
- Latent Profiles of Comorbid Depression as Predictors of PTSD Treatment Outcome.Behavior therapy · 2021Trial
- The role of arousal symptoms in PTSD and depression comorbidity: a longitudinal network analysis among adolescents after a natural disaster.European journal of psychotraumatology · 2026Article
- Personality and Psychotic-Like Features in Post-Traumatic Stress Disorder With Severe Depression: An Minnesota Multiphasic Personality Inventory-2 Schizophrenia Scale Analysis.Psychiatry investigation · 2026Article
- A Feasibility and Acceptability Trial of Narrative Exposure Therapy During Pregnancy.Behavior therapy · 2026Article
- Neuropeptide S pathway in PTSD and neuropsychiatric disorders: A review.Biomolecules & biomedicine · 2025Review
- Long-Term Improvements of Complex Post-Traumatic Stress Disorder (CPTSD) Symptoms After Multimodal Psychodynamic Inpatient Rehabilitation Treatment-An Observational Single Center Pilot Study.Journal of clinical psychology · 2025Observational
- C-reactive protein as a possible indicator of PTSD prognosis and comorbid anhedonia.Brain, behavior, and immunity · 2025Article
- The effects of potentially traumatic events on the recovery from pre-existing anxiety and depression symptomatology and the risk of PTSD.Psychiatry and clinical neurosciences · 2024Article
- Treatment-related beliefs and reactions among trauma-focused therapy completers and discontinuers: A qualitative examination.Psychological services · 2024Article
- Medicinal cannabis for treating post-traumatic stress disorder and comorbid depression: real-world evidence.BJPsych open · 2024Article
- Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review.Current neuropharmacology · 2024Review
- Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity.Psychoradiology · 2024Review
- Anxiety sensitivity and social support in veterans with emotional disorders.Journal of clinical psychology · 2023Article
- Exploring trajectories in transdiagnostic behavior therapy.Journal of traumatic stress · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The co-occurrence of depression with posttraumatic stress disorder (PTSD) is common and associated with greater severity and impairment than PTSD alone, but the effects on PTSD treatment outcomes are unclear. This study investigated the impact of baseline depression on PTSD symptom change and dropout in a meta-analysis of 44 randomized controlled trials (N = 4,866) of trauma-focused psychotherapies for PTSD. Analyses included 107 active (k = 71) and control (k = 36) conditions. Baseline depression was indexed within samples as (a) continuous symptom severity (e.g., Beck Depression Inventory), standardized across depression measures and (b) proportion of patients with comorbid depressive disorder diagnosis. Among active conditions reporting continuous depression scores (k = 62), greater depression severity predicted smaller PTSD treatment effect sizes (ß = -.36, p = .002), but not dropout (ß = .25, p = .18). Categorical depressive diagnosis rates (k = 29)-reported less frequently-were not associated with treatment effects or dropout in active conditions. Greater depression severity may reflect a risk factor for attenuated response in PTSD psychotherapies, potentially demanding complementary strategies within trauma-focused interventions. Variability between trials in baseline depression symptoms may suggest the need to consider this sample characteristic when comparing treatment outcomes across studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.