Evidence map›Paper›PMID 33483110›Full record

Trial reportBehavior therapy2021

Habituation or Normalization? Experiential and Respiratory Recovery From Voluntary Hyperventilation in Treated Versus Untreated Patients With Panic Disorder.

Natalie C Tunnell, Thomas Ritz, Frank H Wilhelm, Walton T Roth, Alicia E Meuret

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Behavior therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Natalie C TunnellSouthern Methodist University. Electronic address: ntunnell@smu.edu.
Thomas RitzSouthern Methodist University.
Frank H WilhelmUniversity of Salzburg.
Walton T RothStanford University and the VA Palo Alto Health Care System.
Alicia E MeuretSouthern Methodist University. Electronic address: ameuret@smu.edu.
Southern Methodist University · USUniversity of Salzburg · ATVA Palo Alto Health Care System · US

Funding

HPA AXIS/DOPAMINE INTERACTIONS IN PSYCHOTIC DEPRESSIONR01MH050604 · NIMH · STANFORD UNIVERSITY · PI SCHATZBERG, ALAN F. · 1994 to 2009
$5.2M
Respiratory Therapeutic Procedures in Panic DisorderR01MH066953 · NIMH · STANFORD UNIVERSITY · PI ROTH, WALTON THOMPSON · 2004 to 2006
$779k
NIMH NIH HHS R01 MH050604NIMH NIH HHS R01 MH066953
6 · The paper itself

Abstract

Psychophysiological theories postulate respiratory dysregulation as a mechanism contributing to panic disorder (PD). Additionally, symptomatic and respiratory recovery from voluntary hyperventilation (HVT-recovery) have been shown to lag in PD and it is unclear if HVT-recovery normalizes with treatment. Thirty-seven panic disorder patients were randomized to hypoventilation therapy (TX, n = 20) or waitlist control (WL, n = 17) (Meuret et al., 2008). In a secondary analysis, their HVT-recovery was analyzed at pre- and post-TX/WL, compared to 29 healthy controls (HC). HVT included three phases: 5-min baseline, 3-min hyperventilation, and 8-min recovery. HVT-elicited symptom severity and anxiety were rated following each phase, and end-tidal PCO

Indexed as

Panic DisorderAnxiety DisordersCarbon DioxideHabituation, PsychophysiologicHumansHyperventilationPanicCarbon Dioxidebehavior therapycarbon dioxidehyperventilationpanic disorderrespiration

Identifiers

PMID33483110
PMCPMC9020269
OpenAlexW3012456090

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.