Evidence map›Paper›PMID 33482968›Full record

Observational studyThe Permanente journal2020

Prevalence and Characteristics of Chronic Cough in Adults Identified by Administrative Data.

Robert S Zeiger, Fagen Xie, Michael Schatz, Benjamin D Hong, Jessica P Weaver, Vishal Bali, Jonathan Schelfhout, Wansu Chen

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in The Permanente journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Diagnosis and Treatment of Adult Patients with Cough.Respiration; international review of thoracic diseases · 2025
    Guideline
  2. Seasonality in Cough: The Influence of Environmental Physiology.Laryngoscope investigative otolaryngology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Robert S ZeigerDepartments of Allergy and Research and Evaluation, Kaiser Permanente Southern California, San Diego and Pasadena, CA.
Fagen XieDepartments of Allergy and Research and Evaluation, Kaiser Permanente Southern California, San Diego and Pasadena, CA.
Michael SchatzDepartments of Allergy and Research and Evaluation, Kaiser Permanente Southern California, San Diego and Pasadena, CA.
Benjamin D HongDepartments of Allergy and Research and Evaluation, Kaiser Permanente Southern California, San Diego and Pasadena, CA.
Jessica P WeaverCenter for Observational and Real-World Evidence (CORE), Merck & Co, Inc, Kenilworth, NJ.
Vishal BaliCenter for Observational and Real-World Evidence (CORE), Merck & Co, Inc, Kenilworth, NJ.
Jonathan SchelfhoutCenter for Observational and Real-World Evidence (CORE), Merck & Co, Inc, Kenilworth, NJ.
Wansu ChenDepartments of Allergy and Research and Evaluation, Kaiser Permanente Southern California, San Diego and Pasadena, CA.
Kaiser Permanente · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextInternational Classification of Diseases-9/10 codes for chronic cough (CC) do not exist, limiting investigation.

objectiveTo develop a computerized algorithm to determine CC prevalence and its characteristics.

designThis observational study using administrative data identified hierarchically patients aged 18 to 85 years with CC from 2013 to 2016. First, a specialist-diagnosed CC group was identified using an internal CC encounter code during an outpatient visit to a pulmonologist, allergist, otolaryngologist, or gastroenterologist. Subsequently, an event-diagnosed CC group was identified based on clinical notes through natural language processing, ICD-9/ICD-10 cough codes, and dispensed antitussives.

main outcome measuresPrevalence of CC and comparison of clinical characteristics between specialist-diagnosed and event-diagnosed CC subgroups.

resultsA total of 50,163 patients with CC of more than 8 weeks were identified. Of these, 11,290 (22.5%) were specialist diagnosed, and 38,873 (77.5%) were event diagnosed. The CC cohort was 57.4 ± 16.5 years of age; 67.6% were female. The overall prevalence was 1.04% (95% confidence interval = 1.03-1.06) in 2016. Prevalence in 2016 was higher in female patients (1.21%) than in male patients (0.81%), higher in patients aged 65 to 85 years (2.2%) than in patients aged 18 to 44 years (0.43%), and higher in Blacks (1.38%) than in Whites (1.21%). Compared with patients with event-diagnosed CC, patients with specialist-diagnosed CC exhibited significantly higher frequencies of laboratory tests and respiratory and nonrespiratory comorbidities and dispensed medication and lower frequency of pneumonia, all-cause and respiratory-cause emergency department visits and hospitalizations, and dispensed antitussives.

conclusionsWe identified a CC cohort using electronic data in a managed care organization. Prevalences varied by sex, age, and ethnicity. Clinical characteristics varied between specialist-diagnosed and event-diagnosed CC.

Indexed as

CoughInternational Classification of DiseasesAdultAgedChronic DiseaseComorbidityFemaleHumansMalePrevalence

Identifiers

PMID33482968
PMCPMC7849260
OpenAlexW3115956216

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.