Evidence map›Paper›PMID 33482930›Full record

ReviewGene expression2021

Integrin Linked Kinase (ILK) and its Role in Liver Pathobiology.

Nicole Martucci, George K Michalopoulos, Wendy M Mars

Open access · hybridAbstract readReview
In one paragraph

Review in Gene expression, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  5. The Expression ofInternational journal of molecular sciences · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nicole MartucciDepartment of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA.
George K MichalopoulosDepartment of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA.
Wendy M MarsDepartment of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA.
University of Pittsburgh · US

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shuchang Silvia Liu · 2019 to 2026
$10.9M
Cellular Approaches to Tissue Engineering/RegenerationT32EB001026 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN, ANDREW W, MONGA, SATDARSHAN SINGH · 2003 to 2024
$5.5M
BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCERR01CA124414 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MONGA, SATDARSHAN SINGH · 2007 to 2011
$1.3M
NCI NIH HHS R01 CA124414NIBIB NIH HHS T32 EB001026NIDDK NIH HHS P30 DK120531
6 · The paper itself

Abstract

Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethora of other common cellular functions. In this review, ILKs role in the liver is detailed. Studies have shown ILK to be a major participant in hepatic ECM organization, liver regeneration, insulin resistance, and hepatocellular carcinoma.

Indexed as

AnimalsHumansLiverLiver DiseasesProtein Serine-Threonine KinasesScaffold Protein ILKSignal TransductionProtein Serine-Threonine KinasesScaffold Protein ILK

Identifiers

PMID33482930
PMCPMC8201652
OpenAlexW3124949718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.