ArticleRadiation oncology (London, England)2021
Delayed postoperative radiotherapy increases the incidence of radiographic local tumor progression before radiotherapy and leads to poor prognosis in spinal metastases.
Article in Radiation oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Application of enhanced recovery after surgery for patients with spinal metastasis: a systematic review and meta-analysis.Journal of neuro-oncology · 2026Pooled it
- Letter to the Editor regarding "Questionable indication for postoperative radiotherapy after surgery for metastases of the major long bones": A cautionary note on methodology and analysis.Journal of bone oncology · 2026Article
- Perspectives and challenges of multidisciplinary collaboration in the treatment of metastatic spinal disease: Insights from an international survey.Neuro-oncology practice · 2026Article
- Pilot study of separation surgery with intraoperative radiotherapy (IORT) for spine metastasis.Journal of bone oncology · 2026Article
- Using Endoscopic Approaches in the Surgical Management of Spinal Metastatic Disease.Journal of clinical medicine · 2026Review
- Development of a Predictive Model for Large-Volume Pleural Effusion After Separation Surgery in Patients With Spinal Metastatic Tumors.Cancer reports (Hoboken, N.J.) · 2025Article
- Microscopically-assisted Uninstrumented Surgical Tumor Decompression as an alternative to open surgery for symptomatic metastatic epidural spinal cord compression.Journal of spine surgery (Hong Kong) · 2025Article
- The Outcomes of Surgical and Nonsurgical Treatment in Patients With Spinal Metastases of Lung Cancer: Protocol for a Prospective Cohort Study.JMIR research protocols · 2023Article
- Spinal metastasis: narrative reviews of the current evidence and treatment modalities.The Journal of international medical research · 2022Review
- Surgical management of spinal metastases from primary thyroid carcinoma: Demographics, clinical characteristics, and treatment outcomes - A retrospective analysis.Journal of craniovertebral junction & spineArticle
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9 authors at 3 institutions in 1 country.
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Abstract
backgroundMost previous studies focused on the minimum interval between surgery and radiotherapy in spinal metastases, leaving the maximum interval under-investigated. However, in real world, limited radiotherapist and equipment cannot meet the needs of a large patient population to obtain timely radiotherapy after the index spine surgery in developing countries. This study aimed to estimate the clinical risks of delayed radiotherapy after surgery in patients with spinal metastases in developing country.
methodsData from 89 patients who underwent surgery and postoperative radiotherapy at a single site in a developing country were retrospectively reviewed. Patients were divided into the progression before radiotherapy (PBR) and no progression before radiotherapy (NPBR) groups. Kaplan-Meier analysis and log-rank tests were used to compare the local control (LC) and overall survival (OS) between groups.
resultsWithin 1 month after surgery, only 20.2% of patients underwent radiotherapy. Risk of local progression before radiotherapy at 1, 3, and 6 months was 1.2%, 24.1%, and 45.1%, respectively. The LC rate at 1 year was lower in the PBR group than in the NPBR group (53.3% vs. 76.3%, P = 0.040). The OS rate at 1 year was 61.9% and 79.6% in the PBR and NPBR groups, respectively (P = 0.001). The Karnofsky performance status significantly improved only in the NPBR group (52.5 ± 17.6 vs. 66.8 ± 26.3, P < 0.001). The sphincter dysfunction significantly improved in the NPBR group (0.3 ± 0.5 vs. 0.1 ± 0.3, P = 0.007) but it tended to be deteriorated in the PBR group (0.1 ± 0.4 vs. 0.3 ± 0.5, P = 0.500).
conclusionsIn real world, about 80% of patients had delayed radiotherapy 1 month after spine surgery for metastases in our developing country. Patients had a higher risk for radiographic local progression before radiotherapy and poorer LC, OS, and quality of life as time to radiotherapy increased.
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