Evidence map›Paper›PMID 33482828›Full record

ReviewJournal of nanobiotechnology2021

Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications.

Gitishree Das, Han-Seung Shin, Estefânia V Ramos Campos, Leonardo Fernandes Fraceto, Maria Del Pilar Rodriguez-Torres, Kelli Cristina Freitas Mariano, Daniele Ribeiro de Araujo, Fabián Fernández-Luqueño, Renato Grillo, Jayanta Kumar Patra

Open access · goldAbstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 123 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Sericin-coated MnOScientific reports · 2025
    Article
  8. Review
  9. Review
  10. Recycled Sericin Biopolymer in Biotechnology and Bioelectronics.Bioengineering (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Sericin Protein: Structure, Properties, and Applications.Journal of functional biomaterials · 2024
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Gitishree DasResearch Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea.ORCID https://orcid.org/0000-0002-5676-0768
Han-Seung ShinDepartment of Food Science & Biotechnology, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea.
Estefânia V Ramos CamposHuman and Natural Sciences Center, Federal University of ABC. Av. Dos Estados, 5001. Bl. A, T3, Lab. 503-3. Bangú, Santo André, SP, Brazil.ORCID https://orcid.org/0000-0002-9420-7461
Leonardo Fernandes FracetoInstitute of Science and Technology of Sorocaba, São Paulo State University (UNESP), Av. Três de março, 511, Alto da Boa Vista, Sorocaba, São Paulo, 18087-180, Brazil.ORCID https://orcid.org/0000-0002-2827-2038
Maria Del Pilar Rodriguez-TorresDepartamento de Ingenieria Molecular de Materiales, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Blvd. Juriquilla 3001, 76230, Queretaro, Qro, Mexico.
Kelli Cristina Freitas MarianoHuman and Natural Sciences Center, Federal University of ABC. Av. Dos Estados, 5001. Bl. A, T3, Lab. 503-3. Bangú, Santo André, SP, Brazil.
Daniele Ribeiro de AraujoHuman and Natural Sciences Center, Federal University of ABC. Av. Dos Estados, 5001. Bl. A, T3, Lab. 503-3. Bangú, Santo André, SP, Brazil.
Fabián Fernández-LuqueñoSustainability of Natural Resources and Energy Programs, Cinvestav-Saltillo, 25900, Coahuila, C.P., Mexico.
Renato GrilloDepartment of Physics and Chemistry, São Paulo State University (UNESP), Avenida Brasil, 56, Centro, Ilha Solteira, SP, 15385-000, Brazil.ORCID https://orcid.org/0000-0002-0284-5782
Jayanta Kumar PatraResearch Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea. jkpatra.cet@gmail.com.ORCID http://orcid.org/0000-0003-4118-4355
Dongguk University · KRUniversidade Federal do ABC · BRCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXUniversidade de Sorocaba · BRUniversidade Estadual Paulista (Unesp) · BRUniversidad Nacional Autónoma de México · MX

Funding

National Research Foundation of Korea 2020R1G1A1004667
6 · The paper itself

Abstract

backgroundThe advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials. MAIN BODY: Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells.

conclusionIn this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.

Indexed as

AnimalsBiocompatible MaterialsBombyxDrug Delivery SystemsHumansNanomedicineNanostructuresNanotechnologySericinsTissue ScaffoldsBiocompatible MaterialsSericinsBiomaterialsBiomedicalDrug deliveryNanoformulationSericinSilk protein

Identifiers

PMID33482828
PMCPMC7821414
OpenAlexW3125204155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.