Evidence map›Paper›PMID 33482806›Full record

ArticleWorld journal of surgical oncology2021

C3 glomerulonephritis along with light chain proximal tubulopathy without crystal deposits in multiple myeloma: a case report.

Junhui Xu, Xiaojuan Yu, Suxia Wang, Miao Yan, Mangju Wang, Jinping Ou, Lihong Wang, Huihui Liu, Xinan Cen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junhui Xu *Department of Hematology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi ChengDistrict, Beijing, 100034, China.
Xiaojuan Yu *Department of Nephrology, Peking University First Hospital, Beijing, China.
Suxia Wang *Laboratory of Electron Microscopy, Pathological Centre, Peking University First Hospital, Beijing, China.
Miao YanDepartment of Hematology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi ChengDistrict, Beijing, 100034, China.
Mangju WangDepartment of Hematology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi ChengDistrict, Beijing, 100034, China.
Jinping OuDepartment of Hematology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi ChengDistrict, Beijing, 100034, China.
Lihong WangDepartment of Hematology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi ChengDistrict, Beijing, 100034, China.
Huihui LiuDepartment of Hematology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi ChengDistrict, Beijing, 100034, China.
Xinan CenDepartment of Hematology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi ChengDistrict, Beijing, 100034, China. cenxn@bjmu.edu.cn.

Funding

Beijing Municipal Science Technology Commission No. Z191100006619026 and Z141107002514017
6 · The paper itself

Abstract

backgroundMultiple myeloma causes different types of renal injury. C3 glomerulonephritis (C3GN) is characterised by an abnormal deposition of complement C3 in the glomeruli due to abnormal activation of the alternative pathway of the complement system. While the association between C3GN and multiple myeloma has been well established, mild renal injury by C3GN in multiple myeloma patients with high levels of light chain has not been reported. CASE PRESENTATION: A 55-year-old Chinese man presented with proteinuria. Combined with immunofixation electrophoresis, bone marrow biopsy, and renal biopsy, he was diagnosed with IgA-type multiple myeloma accompanied by C3GN and light chain proximal tubulopathy without crystal deposits. Although he had a higher level of lambda serum-free light chain, the renal injury in this patient was mild. After treatment with four courses of BD, one course of PAD, and autologous stem cell transplantation, he achieved a very good partial hematologic response with stable renal function.

conclusionsIn multiple myeloma, the light chain reaches a certain level and persists, resulting in C3GN renal impairment. Early diagnosis and early intensive treatment are critical for the prognosis of such patients.

Indexed as

GlomerulonephritisHematopoietic Stem Cell TransplantationMultiple MyelomaHumansMaleMiddle AgedPrognosisTransplantation, AutologousAutologous stem cell transplantationC3 glomerulonephritisLight Chain proximal tubulopathy without crystal depositsMultiple myeloma

Identifiers

PMID33482806
PMCPMC7824921

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