ArticleBMC cancer2021
Depression, anxiety, fatigue, and quality of life in a large sample of patients suffering from head and neck cancer in comparison with the general population.
Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- PTSD in Patients Who Undergo Head and Neck Cancer Treatment: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- A comprehensive examination of mental health in patients with head and neck cancer: systematic review and meta-analysis.JNCI cancer spectrum · 2024Pooled it
- Psychosocial Distress of Head Neck Cancer (HNC) Patients Receiving Radiotherapy: A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2022Pooled it
- Mindfulness-Based Stress Reduction Alleviates Depression, Anxiety, and Internalized Stigma Compared With Treatment-as-Usual Among Head and Neck Cancer Patients: Findings From a Randomized Controlled Trial.Depression and anxiety · 2025Trial
- The Patient Concerns Inventory-Head and Neck (PCI-HN): Swedish Translation and Cultural Adaptation.Scandinavian journal of caring sciences · 2026Article
- Depressive symptoms and perceived stress in patients with head and neck cancer undergoing intensity-modulated radiation therapy: A longitudinal study.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2026Article
- Decisional Conflict in Palliative Head and Neck Cancer Patients.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Multidomain predictors of long-term work disability in late survivorship after head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Health-related quality of life among adult cancer patients with and without HIV: Analysis of SEER-MHOS data (2007-2017).Journal of geriatric oncology · 2026Article
- Caregiver health literacy in head and neck cancer and its relationship with caregiver and patient psychological distress.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Quality of Life and Return to Work After Radiotherapy in Young Adults With Head-and-Neck Cancer-A Bicentric Cross-Sectional Observational Study.Cancer medicine · 2026Observational
- Prognostic significance of dipeptidyl peptidase-7 (DPP7) in HPV16-negative head and neck squamous cell carcinoma treated with induction chemoradiotherapy.Discover oncology · 2025Article
- Article
- Physical activity in people affected by head and neck cancers: gender-specific barriers and preferences-ORLAPA survey results.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Head and Neck Cancer: Trends and Geographical Distribution of Head and Neck Cancer at a Tertiary Hospital in Northern Tanzania.Laryngoscope investigative otolaryngology · 2025Article
- Pre-radiotherapy multidisciplinary survivorship care and patient-reported outcomes in head and neck cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Comparable long term psychosocial burden in patients with lower grade versus higher grade brain tumors.Scientific reports · 2025Article
- The mediating role of resilience in the relationships between posttraumatic growth and depression as well as anxiety among survivors of nasopharyngeal carcinoma: a cross-sectional study.BMC psychology · 2025Article
- Demographic Disparities in Diagnosis and Treatment of Anxiety and Depressive Disorders in Head and Neck Cancer Survivors.Head & neck · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatment of head and neck cancer (HNC) often leads to visible and severe functional impairments. In addition, patients often suffer from a variety of psychosocial problems, significantly associated with a decreased quality of life. We aimed to compare depression, anxiety, fatigue and quality of life (QoL) between HNC patients and a large sample of the general population in Germany and to examine the impact of sociodemographic, behavioral and clinical factors on these symptoms.
methodsWe assessed data of HNC patients during the aftercare consultation at the Leipzig University Medical Center with a patient reported outcome (PRO) tool named "OncoFunction". Depression, anxiety, fatigue and QoL were assessed using validated outcome measures including the PHQ-9, the GAD-2, and the EORTC QLQ-C30 questionnaire.
resultsA total of 817 HNC patients were included in our study and compared to a sample of 5018 individuals of the general German population. HNC patients showed significantly higher levels of impairment in all dimensions assessed. Examination of association between depression, anxiety, fatigue and QoL and clinical as well as sociodemographic variables showed significant relationships between occupational status, ECOG-state, body mass index and time since diagnosis.
conclusionsHNC patients suffer significantly from psychological distress. The used questionnaires are suitable for the use in daily routine practice and can be helpful to increase the detection of depression, anxiety and fatigue and therefore can improve HNC aftercare.
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