Evidence map›Paper›PMID 33482571›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2021

Another 'BEE'? - Brain-Eye-Ear (BEE) Disease Secondary to HbSC Disease Masquerading as Multiple Sclerosis.

Asya Izraelit Wallach, Maria J Borja, Duan Chen, Rachel Eisenberg, Yasha S Modi, Cen Zhang, Timothy M Shepherd, Avindra Nath, Bryan Smith, Jose U Scher and 2 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Multiple sclerosis and sickle cell anemia: when two worlds collide.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Asya Izraelit WallachFormer Affiliation/Place Clinical Care was provided: NYU MS Comprehensive Care Center, Department of Neurology, NYU Langone Health, New York, USA; Current Affiliation/ Place Manuscript was written: Alfiero and Lucia Palestroni MS Comprehensive Care Center, Holy Name Medical Center, New Jersey, USA. Electronic address: awallach@holyname.org.
Maria J BorjaDivision of Neuroradiology, Department of Radiology, NYU Langone Health, New York, USA.
Duan ChenDivision of Neuroradiology, Department of Radiology, NYU Langone Health, New York, USA.
Rachel EisenbergAllergy & Immunology, Department of Pediatrics, Children's Hospital at Montefiore, New York, USA.
Yasha S ModiDepartment of Ophthalmology, NYU Langone Health, New York, USA.
Cen ZhangDivision of Vascular Neurology, Department of Neurology, NYU Langone Health, New York, USA.
Timothy M ShepherdDivision of Neuroradiology, Department of Radiology, NYU Langone Health, New York, USA.
Avindra NathSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke and National Institutes of Health, New York, USA.
Bryan SmithSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke and National Institutes of Health, New York, USA.
Jose U ScherDivision of Rheumatology, Department of Medicine, NYU Langone Health, New York, USA.
Catherine ChoDivision of Otoneurology, Departments of Neurology and Otolaryngology, NYU Langone Health, New York, USA.
Ilya KisterNYU MS Comprehensive Care Center, Department of Neurology, NYU Langone Health, New York, USA.
NYU Langone Health · USNational Institutes of Health · USChildren's Hospital at Montefiore · USHoly Name Medical Center · US

Funding

Neuropathogenesis of Retroviral InfectionsZIANS003130 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2011 to 2025
$73.7M
Intramural NIH HHS ZIA NS003130
6 · The paper itself

Abstract

Recurrent episodes of neurological dysfunction and white matter lesions in a young adult raise suspicion for multiple sclerosis (MS). However, occlusive retinopathy, hearing loss and absence of CSF oligoclonal bands are atypical for MS and should make the clinician consider an alternative diagnosis. We describe a man with hearing loss, visual signs and symptoms, and an accumulating burden of brain lesions, who was treated for a clinical diagnosis of MS for nearly two decades. Genetic testing revealed a unifying diagnosis.

Indexed as

Exome SequencingDiagnostic ErrorsGenetic Predisposition to DiseaseHearing Loss, UnilateralHemoglobins, AbnormalHemoglobin SC DiseaseHumansLeukoencephalopathiesMagnetic Resonance ImagingMaleMultiple SclerosisPhenotypePredictive Value of TestsVision DisordersYoung AdultHemoglobins, AbnormalBrain-eye-ear diseaseHbSC diseaseHemoglobinopathyMultiple sclerosisSickle cell diseaseWhole exome sequencing

Identifiers

PMID33482571
PMCPMC11339433
OpenAlexW3124439442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.