Evidence map›Paper›PMID 33482149›Full record

ReviewBiochemical pharmacology2021

Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics.

Li Zeng, Dongying Li, Weida Tong, Tieliu Shi, Baitang Ning

Open access · greenAbstract readReview
In one paragraph

Review in Biochemical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. RedefiningMolecular therapy. Nucleic acids · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Li ZengChangde Research Centre for Artificial Intelligence and Biomedicine, College of Life and Environmental Sciences, Hunan University of Arts and Science, Changde, Hunan 415000, China.
Dongying LiNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, 72079, United States.
Weida TongNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, 72079, United States.
Tieliu ShiChangde Research Centre for Artificial Intelligence and Biomedicine, College of Life and Environmental Sciences, Hunan University of Arts and Science, Changde, Hunan 415000, China. Electronic address: teiliushi@yahoo.com.
Baitang NingNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, 72079, United States. Electronic address: baitang.ning@fda.hhs.gov.
Hunan University of Arts and Science · CNUnited States Food and Drug Administration · USNational Center for Toxicological Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Three viral proteins, the spike protein (S) for attachment of virus to host cells, 3-chymotrypsin-like cysteine protease (M

Indexed as

COVID-19 Drug TreatmentAnimalsAntiviral AgentsCOVID-19Drug ApprovalDrug DevelopmentHumansMutationRNASARS-CoV-2Spike Glycoprotein, CoronavirusAntiviral AgentsRNASpike Glycoprotein, CoronavirusCOVID-19Drug safety and drug efficacyMutationRNA therapeuticsSARS-CoV-2

Identifiers

PMID33482149
PMCPMC7816569
OpenAlexW3124383924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.