Evidence map›Paper›PMID 33481842›Full record

ArticlePloS one2021

Gestational breast cancer in New South Wales: A population-based linkage study of incidence, management, and outcomes.

Nadom Safi, Christobel Saunders, Andrew Hayen, Antoinette Anazodo, Kei Lui, Zhuoyang Li, Marc Remond, Michael Nicholl, Alex Y Wang, Elizabeth Sullivan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis.Mayo Clinic proceedings. Innovations, quality & outcomes · 2024
    Review
  5. Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nadom SafiSchool of Public Health, University of Technology Sydney, Sydney, NSW, Australia.ORCID 0000-0001-8473-0980
Christobel SaundersFaculty of Health and Medical Sciences, The University of Western Australia, Crawley, WA, Australia.
Andrew HayenSchool of Public Health, University of Technology Sydney, Sydney, NSW, Australia.
Antoinette AnazodoSchool of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia.
Kei LuiSchool of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia.
Zhuoyang LiFaculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.
Marc RemondFaculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.
Michael NichollFaculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Alex Y WangSchool of Public Health, University of Technology Sydney, Sydney, NSW, Australia.
Elizabeth SullivanSchool of Public Health, University of Technology Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of gestational breast cancer (GBC) is increasing in high-income countries. Our study aimed to examine the epidemiology, management and outcomes of women with GBC in New South Wales (NSW), Australia.

methodsA retrospective cohort study using linked data from three NSW datasets. The study group comprised women giving birth with a first-time diagnosis of GBC while the comparison group comprised women giving birth without any type of cancer. Outcome measures included incidence of GBC, maternal morbidities, obstetric management, neonatal mortality, and preterm birth.

resultsBetween 1994 and 2013, 122 women with GBC gave birth in NSW (crude incidence 6.8/ 100,000, 95%CI: 5.6-8.0). Women aged ≥35 years had higher odds of GBC (adjusted odds ratio (AOR) 6.09, 95%CI 4.02-9.2) than younger women. Women with GBC were more likely to give birth by labour induction or pre-labour CS compared to women with no cancer (AOR 4.8, 95%CI: 2.96-7.79). Among women who gave birth by labour induction or pre-labour CS, the preterm birth rate was higher for women with GBC than for women with no cancer (52% vs 7%; AOR 17.5, 95%CI: 11.3-27.3). However, among women with GBC, preterm birth rate did not differ significantly by timing of diagnosis or cancer stage. Babies born to women with GBC were more likely to be preterm (AOR 12.93, 95%CI 8.97-18.64), low birthweight (AOR 8.88, 95%CI 5.87-13.43) or admitted to higher care (AOR 3.99, 95%CI 2.76-5.76) than babies born to women with no cancer.

conclusionWomen aged ≥35 years are at increased risk of GBC. There is a high rate of preterm birth among women with GBC, which is not associated with timing of diagnosis or cancer stage. Most births followed induction of labour or pre-labour CS, with no major short term neonatal morbidity.

Indexed as

AdultBreast NeoplasmsCohort StudiesFemaleHospitalizationHumansIncidenceInfant, NewbornLabor, InducedNeoplasm StagingNew South WalesPregnancyPregnancy ComplicationsPrognosisRetrospective Studies

Identifiers

PMID33481842
PMCPMC7822528

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.