Evidence map›Paper›PMID 33481820›Full record

ArticlePloS one2021

Improvement of image quality and assessment of respiratory motion for hepatocellular carcinoma with portal vein tumor thrombosis using contrast-enhanced four-dimensional dual-energy computed tomography.

Shingo Ohira, Naoyuki Kanayama, Kentaro Wada, Toshiki Ikawa, Takero Hirata, Noriko Kishi, Tsukasa Karino, Hayate Washio, Yoshihiro Ueda, Masayoshi Miyazaki and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Shingo OhiraDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.ORCID 0000-0002-6170-1471
Naoyuki KanayamaDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Kentaro WadaDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Toshiki IkawaDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.ORCID 0000-0001-9097-0227
Takero HirataDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Noriko KishiDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.ORCID 0000-0001-5007-8808
Tsukasa KarinoDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Hayate WashioDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Yoshihiro UedaDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Masayoshi MiyazakiDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Masahiko KoizumiDepartment of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Japan.
Teruki TeshimaDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Osaka International Cancer Institute · JPKyoto University · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess the objective and subjective image quality, and respiratory motion of hepatocellular carcinoma with portal vein tumor thrombosis (PVTT) using the contrast-enhanced four-dimensional dual-energy computed tomography (CE-4D-DECT). For twelve patients, the virtual monochromatic image (VMI) derived from the CE-4D-DECT with the highest contrast to noise ratio (CNR) was determined as the optimal VMI (O-VMI). To assess the objective and subjective image quality, the CNR and five-point score of the O-VMI were compared to those of the standard VMI at 77 keV (S-VMI). The respiratory motion of the PVTT and diaphragm was measured based on the exhale and inhale phase images. The VMI at 60 keV yielded the highest CNR (4.8 ± 1.4) which was significantly higher (p = 0.02) than that in the S-VMI (3.8 ± 1.2). The overall image quality (4.0 ± 0.6 vs 3.1 ± 0.5) and tumor conspicuity (3.8 ± 0.8 vs 2.8 ± 0.6) of the O-VMI determined by three radiation oncologists was significantly higher (p < 0.01) than that of the S-VMI. The diaphragm motion in the L-R (3.3 ± 2.5 vs 1.2 ± 1.1 mm), A-P (6.7 ± 4.0 vs 1.6 ± 1.3mm) and 3D (8.8 ± 3.5 vs 13.1 ± 4.9 mm) directions were significantly larger (p < 0.05) compared to the tumor motion. The improvement of objective and subjective image quality was achieved in the O-VMI. Because the respiratory motion of the diaphragm was larger than that of the PVTT, we need to be pay attention for localizing target in radiotherapy.

Indexed as

Four-Dimensional Computed TomographyAgedCarcinoma, HepatocellularContrast MediaDiaphragmFemaleHumansImage Interpretation, Computer-AssistedLiver NeoplasmsMaleMiddle AgedPortal VeinRetrospective StudiesSignal-To-Noise RatioThrombosisContrast Media

Identifiers

PMID33481820
PMCPMC7822294
OpenAlexW3123216813

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.