Evidence map›Paper›PMID 33481725›Full record

ArticleIEEE journal of biomedical and health informatics2021

Classification and Prediction of Post-Trauma Outcomes Related to PTSD Using Circadian Rhythm Changes Measured via Wrist-Worn Research Watch in a Large Longitudinal Cohort.

Ayse S Cakmak, Erick A Perez Alday, Giulia Da Poian, Ali Bahrami Rad, Thomas J Metzler, Thomas C Neylan, Stacey L House, Francesca L Beaudoin, Xinming An, Jennifer S Stevens and 38 more

Open access · greenAbstract read
In one paragraph

Article in IEEE journal of biomedical and health informatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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  11. The 2023 wearable photoplethysmography roadmap.Physiological measurement · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 2 countries.

Ayse S Cakmak
Erick A Perez Alday
Giulia Da Poian
Ali Bahrami Rad
Thomas J Metzler
Thomas C Neylan
Stacey L House
Francesca L Beaudoin
Xinming An
Jennifer S Stevens
Donglin Zeng
Sarah D Linnstaedt
Tanja Jovanovic
Laura T Germine
Kenneth A Bollen
Scott L Rauch
Christopher A Lewandowski
Phyllis L Hendry
Sophia Sheikh
Alan B Storrow
Paul I Musey
John P Haran
Christopher W Jones
Brittany E Punches
Robert A Swor
Nina T Gentile
Meghan E McGrath
Mark J Seamon
Kamran Mohiuddin
Anna M Chang
Claire Pearson
Robert M Domeier
Steven E Bruce
Brian J O'Neil
Niels K Rathlev
Leon D Sanchez
Robert H Pietrzak
Jutta Joormann
Deanna M Barch
Diego A Pizzagalli
Steven E Harte
James M Elliott
Ronald C Kessler
Karestan C Koenen
Kerry J Ressler
Samuel A Mclean
Qiao Li
Gari D Clifford
Emory University · USUniversity of North Carolina at Chapel Hill · USHarvard University · USWayne State University · USMcLean Hospital · USUniversity of California, San Francisco · USUniversity of Florida · USWashington University in St. Louis · USYale University · USBaystate Medical Center · USBeth Israel Deaconess Medical Center · USBoston Medical Center · USBrown University · USCooper Medical School of Rowan University · USEinstein Medical Center Philadelphia · USETH Zurich · CHGeorgia Institute of Technology · USHenry Ford Health System · USIndiana University School of MedicineJefferson University Hospitals · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Training Program in Psychiatric Genetics and Translational ResearchT32MH017119 · NIMH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KARESTAN C KOENEN, Jukka-Pekka Onnela · 1985 to 2026
$8.9M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS T32 MH017119NIMH NIH HHS U01 MH110925
6 · The paper itself

Abstract

Post-Traumatic Stress Disorder (PTSD) is a psychiatric condition resulting from threatening or horrifying events. We hypothesized that circadian rhythm changes, measured by a wrist-worn research watch are predictive of post-trauma outcomes. APPROACH: 1618 post-trauma patients were enrolled after admission to emergency departments (ED). Three standardized questionnaires were administered at week eight to measure post-trauma outcomes related to PTSD, sleep disturbance, and pain interference with daily life. Pulse activity and movement data were captured from a research watch for eight weeks. Standard and novel movement and cardiovascular metrics that reflect circadian rhythms were derived using this data. These features were used to train different classifiers to predict the three outcomes derived from week-eight surveys. Clinical surveys administered at ED were also used as features in the baseline models.

resultsThe highest cross-validated performance of research watch-based features was achieved for classifying participants with pain interference by a logistic regression model, with an area under the receiver operating characteristic curve (AUC) of 0.70. The ED survey-based model achieved an AUC of 0.77, and the fusion of research watch and ED survey metrics improved the AUC to 0.79. SIGNIFICANCE: This work represents the first attempt to predict and classify post-trauma symptoms from passive wearable data using machine learning approaches that leverage the circadian desynchrony in a potential PTSD population.

Indexed as

Stress Disorders, Post-TraumaticCircadian RhythmCohort StudiesHumansROC CurveWrist

Identifiers

PMID33481725
PMCPMC8395207
OpenAlexW3125605386

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.