Evidence map›Paper›PMID 33481638›Full record

ReviewExpert review of vaccines2021

Progress towards the development of a

Sai Lata De, Francis B Ntumngia, Justin Nicholas, John H Adams

Abstract readReview
In one paragraph

Review in Expert review of vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. An mRNA-lipid nanoparticle vaccine targeting theMolecular therapy. Nucleic acids · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Naturally acquired antibodies toFrontiers in immunology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Natural genetic diversity of the DBL domain of a novel member of the Plasmodium vivax erythrocyte binding-like proteins (EBP2) in the Amazon rainforest.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024
    Article
  13. Article
  14. Sterile protection againstLife science alliance · 2024
    Article
  15. Article
  16. A two-dose viral-vectoredFrontiers in immunology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sai Lata DeCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, FL, USA.
Francis B NtumngiaCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, FL, USA.
Justin NicholasCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, FL, USA.
John H AdamsCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, FL, USA.

Funding

Immunological characterization of the P. vivax DBPR01AI064478 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI ADAMS, JOHN H · 2006 to 2023
$9.6M
Accelerating discovery of an efficacious Plasmodium vivax multivalent multi-stage vaccineU01AI155361 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI ADAMS, JOHN H · 2021 to 2025
$4.8M
Structural Vaccinology and Design of Novel Imunogens for Malaria Vaccine DevelopmentR01AI137162 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2018 to 2022
$3.6M
NIAID NIH HHS R01 AI064478NIAID NIH HHS R01 AI137162NIAID NIH HHS U01 AI155361
6 · The paper itself

Abstract

introductionAREAS COVERED: Despite decades of research, the complex life cycle, technical challenges and a lack of funding have hampered progress of EXPERT OPINION: A vaccine that presents functionally-conserved epitopes from multiple antigens from various stages of the parasite life cycle is key to induce broadly neutralizing strain-transcending protective immunity to effectively disrupt parasite development and transmission.

Indexed as

AnimalsAntigens, ProtozoanDrug ResistanceHumansLiverMalaria VaccinesMalaria, VivaxPlasmodium vivaxRecurrenceTime FactorsAntigens, ProtozoanMalaria VaccinesClinical trialsheterologous prime/boost immunizationsviral vectorsvirus-like particlesvivax vaccines

Identifiers

PMID33481638
PMCPMC7994195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.