ArticlePharmacological reports : PR2021
Maternal L-thyroxine treatment during lactation affects learning and anxiety-like behaviors but not spatial memory in adult rat progeny.
Article in Pharmacological reports : PR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe present study compared behavioral and molecular indicators of hippocampal function in L-thyroxine treated rats to determine whether thyroid hormone excessiveness produces relatively stable lifelong changes.
methodsHyperthyroidism was induced in rats by daily injections of L-thyroxine (0.2 mg/kg) to their dams for lactation period (MOH: maternal-onset hyperthyroidism) or to the rats itself during the young adult period (AOH: adult-onset hyperthyroidism; between the day 39-60). Spatial learning was assessed in the Morris Water Maze (MWM). Levels of type 2 and type 3 deiodinases, Erk1/2, JNK and P38
resultsIn MWM, maternally treated rats with L-thyroxine swam more away from the hidden platform, with showing more anxiety-like behavior, as compared to the rats treated or no treated with L-thyroxine in young adulthood. In spite of impaired acquisition, MOH group was not significantly different from the other groups in probe trial. In Western blot of the hippocampus, a decreased the expression of P38MAPK was found in rats treated with L-thyroxine in young adulthood period. However, maternal treatment with L-thyroxine resulted in an increased expression of Type 2 deiodinase and a tendency toward decreased expression of total and phosphorylated ERK1/2. No detectable band for type 3 deiodinase, p-JNK and p-P38
conclusionThese results suggest that perinatal excessiveness of thyroid hormone has longstanding effects on hippocampal function and may account for memory problems experienced by adolescents with lactational hyperthyroidism.
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