ReviewOncology and therapy2021
Current Challenges Faced by Cancer Clinical Trials in Addressing the Problem of Under-Representation of Older Adults: A Narrative Review.
Review in Oncology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of immune checkpoint inhibitors for locoregionally advanced, recurrent and metastatic nasopharyngeal carcinoma: a systematic review of phase III randomised controlled trials.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- Development and validation of a SEER-based prognostic nomogram for overall survival in elderly Asian American women with breast cancer.Gland surgery · 2026Article
- The Invisible Barrier of Neighborhood Disadvantage in Clinical Trial Recruitment and Retention Among Older Adults.Journal of the American Geriatrics Society · 2026Article
- Of Barriers and Loops-How Evolution Limits Most Cancer Risks to Older Ages.Cancer discovery · 2026Review
- Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward.Drugs & aging · 2025Review
- Understanding Associations Between Patient-Level Factors and Participation in a Breast Cancer Clinical Trial.Cancer medicine · 2025Article
- Health-related quality of life trajectories among older breast cancer survivors: a SEER-MHOS analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Clinical trials in older patients with cancer - typical challenges, possible solutions, and a paradigm of study design in breast cancer.Acta oncologica (Stockholm, Sweden) · 2024Review
- Optimizing clinical nutrition research: the role of adaptive and pragmatic trials.European journal of clinical nutrition · 2023Review
- Equality, diversity, and inclusion in oncology clinical trials: an audit of essential documents and data collection against INCLUDE under-served groups in a UK academic trial setting.BMC medical ethics · 2023Article
- A nomogram for predicting breast cancer specific survival in elderly patients with breast cancer: a SEER population-based analysis.BMC geriatrics · 2023Article
- Resectability, Resections, Survival Outcomes, and Quality of Life in Older Adult Patients with Metastatic Colorectal Cancer (the RAXO-Study).Journal of clinical medicine · 2023Article
- 'What price do you put on your health?': Medical cannabis, financial toxicity and patient perspectives on medication access in advanced cancer.Health expectations : an international journal of public participation in health care and health policy · 2023Article
- Article
- Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer.Cost effectiveness and resource allocation : C/E · 2022Review
- Challenges in Geriatric Oncology-A Surgeon's Perspective.Current oncology (Toronto, Ont.) · 2022Review
- American Society of Clinical Oncology 2021 Podcast: HR+, HER2- Breast Cancer.Oncology and therapy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The number of older adults living with cancer is increasing. There is a clear lack of representation of older adults in clinical trials, including cancer trials. Reasons for this are multifactorial and complex and include protocol, patient and sponsor factors. Potential solutions to overcome issues with trial design include varied methods of recruitment with flexible inclusion criteria. Possible alternatives to randomised trials include prospective cohort studies, pragmatic trials and the use of national population-based data sets. Patient factors may be addressed by integration of geriatric assessment, so patients can be randomised or treated based on their individual needs. Additionally, standard protocols for including older adults with cognitive impairment should be developed, rather than automatic exclusion. Increased effort is needed from sponsors and governing health care bodies to make recruitment of older adults to clinical trials standard.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.