ArticleMolecular biology and evolution2021
Integrating Linguistics, Social Structure, and Geography to Model Genetic Diversity within India.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Human genetic diversity across South Asian populations: A systematic review and meta-analysis.Medicine · 2025Pooled it
- Clinical and serological association of plasma 25-hydroxyvitamin D (25(OH)D) levels in lupus and the short-term effects of oral vitamin D supplementation.Arthritis research & therapy · 2023Trial
- Geographic barrier contributed to the diversity of maternal and paternal lineages in New Guinea Island.Human genetics · 2026Article
- Integrated genetic and geographic ancestry prediction via large-scale genomic data and machine learning.Human genomics · 2025Article
- Forensic Characterization, Genomic Variability and Ancestry Analysis of Six Populations from Odisha Using mtDNA SNPs and Autosomal STRs.Biochemical genetics · 2025Article
- Genetic insights into forensic features and population structure of the Hajong tribe in the Indian regions of Eastern Himalaya.Molecular genetics and genomics : MGG · 2025Article
- Matrix sketching framework for linear mixed models in association studies.Genome research · 2024Article
- Editorial: The adaptive value of languages: non-linguistic causes of language diversity, volume II.Frontiers in psychology · 2024Article
- Populations of Latvia and Lithuania in the context of some Indo-European and non-Indo-European speaking populations of Europe and India: insights from genetic structure analysis.Frontiers in genetics · 2024Article
- Genomic analysis reveals geography rather than culture as the predominant factor shaping genetic variation in northern Kenyan human populations.American journal of biological anthropology · 2022Article
- Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations.Nature reviews. Endocrinology · 2022Review
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5 authors at 1 institution in 1 country.
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Abstract
India represents an intricate tapestry of population substructure shaped by geography, language, culture, and social stratification. Although geography closely correlates with genetic structure in other parts of the world, the strict endogamy imposed by the Indian caste system and the large number of spoken languages add further levels of complexity to understand Indian population structure. To date, no study has attempted to model and evaluate how these factors have interacted to shape the patterns of genetic diversity within India. We merged all publicly available data from the Indian subcontinent into a data set of 891 individuals from 90 well-defined groups. Bringing together geography, genetics, and demographic factors, we developed Correlation Optimization of Genetics and Geodemographics to build a model that explains the observed population genetic substructure. We show that shared language along with social structure have been the most powerful forces in creating paths of gene flow in the subcontinent. Furthermore, we discover the ethnic groups that best capture the diverse genetic substructure using a ridge leverage score statistic. Integrating data from India with a data set of additional 1,323 individuals from 50 Eurasian populations, we find that Indo-European and Dravidian speakers of India show shared genetic drift with Europeans, whereas the Tibeto-Burman speaking tribal groups have maximum shared genetic drift with East Asians.
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