ArticleMolecular biology and evolution2021
Maintenance of Adaptive Dynamics and No Detectable Load in a Range-Edge Outcrossing Plant Population.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Local Selection Shaped the Diversity of European Maize Landraces.Molecular ecology · 2025Article
- Margins of adaptation at the desert frontier: genetic responses of Ammopiptanthus mongolicus in arid northwestern China.Botanical studies · 2025Review
- Whole-genome duplication increases genetic diversity and load in outcrossingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- DivergingEvolution letters · 2025Article
- Multiple Autopolyploid Arabidopsis lyrata Populations Stabilized by Long-Range Adaptive Introgression Across Eurasia.Molecular biology and evolution · 2025Article
- Mutational load and adaptive variation are shaped by climate and species range dynamics in Vitis arizonica.The New phytologist · 2025Article
- Dominance between self-incompatibility alleles determines the mating system ofEvolution letters · 2024Article
- Forces driving transposable element load variation during Arabidopsis range expansion.The Plant cell · 2024Article
- Using Computational Simulations to Model Deleterious Variation and Genetic Load in Natural Populations.The American naturalist · 2023Review
- Between but Not Within-Species Variation in the Distribution of Fitness Effects.Molecular biology and evolution · 2023Article
- Allele surfing causes maladaptation in a Pacific salmon of conservation concern.PLoS genetics · 2023Article
- Transition to Self-compatibility Associated With Dominant S-allele in a Diploid Siberian Progenitor of Allotetraploid Arabidopsis kamchatica Revealed by Arabidopsis lyrata Genomes.Molecular biology and evolution · 2023Article
- Genetic variation of Cerastium alpinum L. from Babia Góra, a critically endangered species in Poland.Journal of applied genetics · 2023Article
- Article
- Whole-genome sequencing and genome regions of special interest: Lessons from major histocompatibility complex, sex determination, and plant self-incompatibility.Molecular ecology · 2021Article
- Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity.Nature communications · 2021Article
- The inflated significance of neutral genetic diversity in conservation genetics.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Drivers of linkage disequilibrium across a species' geographic range.PLoS genetics · 2021Article
- Polygenic adaptation of rosette growth in Arabidopsis thaliana.PLoS genetics · 2021Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
During range expansion, edge populations are expected to face increased genetic drift, which in turn can alter and potentially compromise adaptive dynamics, preventing the removal of deleterious mutations and slowing down adaptation. Here, we contrast populations of the European subspecies Arabidopsis lyrata ssp. petraea, which expanded its Northern range after the last glaciation. We document a sharp decline in effective population size in the range-edge population and observe that nonsynonymous variants segregate at higher frequencies. We detect a 4.9% excess of derived nonsynonymous variants per individual in the range-edge population, suggesting an increase of the genomic burden of deleterious mutations. Inference of the fitness effects of mutations and modeling of allele frequencies under the explicit demographic history of each population predicts a depletion of rare deleterious variants in the range-edge population, but an enrichment for fixed ones, consistent with the bottleneck effect. However, the demographic history of the range-edge population predicts a small net decrease in per-individual fitness. Consistent with this prediction, the range-edge population is not impaired in its growth and survival measured in a common garden experiment. We further observe that the allelic diversity at the self-incompatibility locus, which ensures strict outcrossing and evolves under negative frequency-dependent selection, has remained unchanged. Genomic footprints indicative of selective sweeps are broader in the Northern population but not less frequent. We conclude that the outcrossing species A. lyrata ssp. petraea shows a strong resilience to the effect of range expansion.
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