Evidence map›Paper›PMID 33480814›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2021

Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis.

C L de Mol, A L Bruijstens, P R Jansen, Mhg Dremmen, Yym Wong, A van der Lugt, Tjh White, R F Neuteboom

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In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

C L de MolDepartment of Neurology, MS Center ErasMS, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-3733-1706
A L BruijstensDepartment of Neurology, MS Center ErasMS, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-7990-5894
P R JansenDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands Department of Clinical Genetics, Amsterdam UMC, Amsterdam, The Netherlands.
Mhg DremmenThe Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Yym WongDepartment of Neurology, MS Center ErasMS, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
A van der LugtDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Tjh WhiteDepartment of Child and Adolescent Psychiatry, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
R F NeuteboomDepartment of Neurology, MS Center ErasMS, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown.

objectiveThe objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children.

methodsWe used data from the Generation R study to identify the childhood RIS prevalence.

resultsIn 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00-0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred.

conclusionsThis study shows that the occurrence of RIS in children from the general population is rare.

Indexed as

Demyelinating DiseasesMultiple SclerosisChildHumansMagnetic Resonance ImagingPrevalencecase reportsepidemiologymultiple sclerosispediatricsprevalenceRadiologically isolated syndrome

Identifiers

PMID33480814
PMCPMC8474308

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