Evidence map›Paper›PMID 33480689›Full record

ArticleJournal of natural products2021

Bifunctional Doscadenamides Activate Quorum Sensing in Gram-Negative Bacteria and Synergize with TRAIL to Induce Apoptosis in Cancer Cells.

Xiao Liang, Qi-Yin Chen, Gustavo M Seabra, Susan Matthew, Jason C Kwan, Chenglong Li, Valerie J Paul, Hendrik Luesch

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiao LiangDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
Qi-Yin ChenDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
Gustavo M SeabraDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-1303-4483
Susan MatthewDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
Jason C KwanDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
Chenglong LiDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
Valerie J PaulSmithsonian Marine Station, Fort Pierce, Florida 34949, United States.ORCID 0000-0002-4691-1569
Hendrik LueschDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-4091-7492
University of Florida · USSmithsonian Marine Station · US

Funding

Novel Targeted Anticancer Agents from Marine CyanobacteriaR01CA172310 · NCI · UNIVERSITY OF FLORIDA · PI HENDRIK LUESCH · 2013 to 2026
$5.8M
NCI NIH HHS R01 CA172310
6 · The paper itself

Abstract

New cyanobacteria-derived bifunctional analogues of doscadenamide A, a LasR-dependent quorum sensing (QS) activator in

Indexed as

TNF-Related Apoptosis-Inducing LigandApoptosisCell Line, TumorCyanobacteriaHumansMolecular StructurePseudomonas aeruginosaPyrrolesQuorum SensingStructure-Activity RelationshipVibriodoscadenamide APyrrolesTNF-Related Apoptosis-Inducing LigandTNFSF10 protein, human

Identifiers

PMID33480689
PMCPMC8209783
OpenAlexW3122627822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.