ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Brain structures and networks responsible for stimulation-induced memory flashbacks during forniceal deep brain stimulation for Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01608061 (A Twelve Month Double-blind Randomized Controlled Feasibility Study to Evaluate the Safety, Efficacy and Tolerability of Deep Brain Stimulation of the Fornix), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Twelve Month Double-blind Randomized Controlled Feasibility Study to Evaluate the Safety, Efficacy and Tolerability of Deep Brain Stimulation of the Fornix (DBS-f) in Patients With Mild Probable Alzheimer's Disease
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- An updated overview of recent and ongoing deep brain stimulation (DBS) trials in patients with dementia: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- Connectomic neuromodulation for Alzheimer's disease: A systematic review and meta-analysis of invasive and non-invasive techniques.Translational psychiatry · 2022Pooled it
- Mapping autonomic, mood and cognitive effects of hypothalamic region deep brain stimulation.Brain : a journal of neurology · 2021Trial
- Long-term efficacy of anterior nucleus of the thalamus deep brain stimulation in drug-resistant epilepsy: a 5-year multicenter study.BMC medicine · 2025Article
- Biomarker changes associated with fornix deep brain stimulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer's Disease.International journal of molecular sciences · 2025Article
- Toward a standard preoperative MRI protocol for functional neurosurgery.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease.Heliyon · 2024Review
- Prescription Opioids and Brain Structure in Community-Dwelling Older Adults.Mayo Clinic proceedings · 2024Article
- Computational Neurosurgery in Deep Brain Stimulation.Advances in experimental medicine and biology · 2024Review
- Brain stimulation and elicited memories.Acta neurochirurgica · 2023Review
- Article
- Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks.NeuroImage · 2023Article
- Innovative perspectives in limbic surgery using deep brain stimulation.Frontiers in neuroscience · 2023Review
- Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease.Nature communications · 2022Article
- Does the Application of Deep Brain Stimulation to Modulate Memory and Neural Circuity in AD Hold Substantial Promise?Neuroscience bulletin · 2022Article
- Untapped Neuroimaging Tools for Neuro-Oncology: Connectomics and Spatial Transcriptomics.Cancers · 2022Article
- Identifying the neural network for neuromodulation in epilepsy through connectomics and graphs.Brain communications · 2022Article
- Review
- Brain structures and networks responsible for stimulation-induced memory flashbacks during forniceal deep brain stimulation for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
Corrections and comments
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Authors and funding
22 authors at 13 institutions in 3 countries.
Funding
Abstract
introductionFornix deep brain stimulation (fx-DBS) is under investigation for treatment of Alzheimer's disease (AD). We investigated the anatomic correlates of flashback phenomena that were reported previously during acute diencephalic stimulation.
methodsThirty-nine patients with mild AD who took part in a prior fx-DBS trial (NCT01608061) were studied. After localizing patients' implanted electrodes and modeling the volume of tissue activated (VTA) by DBS during systematic stimulation testing, we performed (1) voxel-wise VTA mapping to identify flashback-associated zones; (2) machine learning-based prediction of flashback occurrence given VTA overlap with specific structures; (3) normative functional connectomics to define flashback-associated brain-wide networks.
resultsA distinct diencephalic region was associated with greater flashback likelihood. Fornix, bed nucleus of stria terminalis, and anterior commissure involvement predicted memory events with 72% accuracy. Flashback-inducing stimulation exhibited greater functional connectivity to a network of memory-evoking and autobiographical memory-related sites. DISCUSSION: These results clarify the neuroanatomical substrates of stimulation-evoked flashbacks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.