ArticleJournal of clinical laboratory analysis2021
Establishment of age- and sex-specific reference intervals for serum liver function tests in pediatric population aged 1-<18 years: A prospective study.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Reference intervals for serum albumin, total protein, and prealbumin in healthy children in Nanning, China.Biomarkers in medicine · 2025Article
- Vertebral fractures and bone health in patients with chronic non-bacterial osteomyelitis at disease onset: insights from the monocentric CAMELOT cohort.Therapeutic advances in musculoskeletal disease · 2025Article
- Exploring the complex dynamics of BMI, age, and physiological indicators in early adolescents.BMC pediatrics · 2024Article
- Effects of essential mineral elements deficiency and supplementation on serum mineral elements concentration and biochemical parameters in grazing Mongolian sheep.Frontiers in veterinary science · 2023Article
- [Differentiate between the reference interval and the clinical diagnosis and treatment decision threshold for alanine aminotransferase].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021Article
- Reference intervals for 26 common biochemical analytes in term neonates in Jilin Province, China.BMC pediatrics · 2021Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe diagnosis, treatment, and prognosis of pediatric diseases rely on the accurate establishment of the reference interval (RI). This study aimed to establish pediatric RIs for liver function tests and evaluated the correlation of the analytes.
methodsPediatric population (aged 1-<18 years) was prospectively recruited in Jilin Province, China. Analytes detected by Ortho VITORS 5600 automatic biochemical analyzer. All strata were divided using the regression tree and Harris and Boyd's method. The dynamic changes of RI were evaluated by the lambda-mu-sigma method.
resultsReference individuals were comprised of 6,322 children and adolescents. Age and sex differences were present in all analytes except serum total protein. The serum albumin, total protein, γ-glutamyl transferase, total bilirubin, and unconjugated bilirubin levels increased with age while serum aspartate aminotransferase was opposite. The serum alanine aminotransferase level reached a trough at the age of 5 and later steadily in males but slowly decreased in females. The serum alkaline phosphatase level dropped rapidly after reaching a peak at 9 years old in females and 12 years old in males. RIs were divided into 11 partitions at most and 5 partitions at least. The strongest correlation between analytes was total bilirubin and unconjugated bilirubin (r = 0.788), followed by total bilirubin and albumin (r = 0.511).
conclusionsAnalytes show unique dynamic changes in pediatric population. The correlations among liver function tests can inform future studies of particular variables. Age- and sex-special pediatric RIs should be established to help an accurate diagnosis of disease.
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