Evidence map›Paper›PMID 33479928›Full record

ArticleJournal of general internal medicine2021

To Expand the Evidence Base About Harms from Tests and Treatments.

Deborah Korenstein, Russell Harris, Adam G Elshaug, Joseph S Ross, Daniel J Morgan, Richelle J Cooper, Hyung J Cho, Jodi B Segal

Abstract read
In one paragraph

Article in Journal of general internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deborah KorensteinDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. korenstd@mskcc.org.ORCID 0000-0003-1859-0574
Russell HarrisUNC School of Medicine, Chapel Hill, NC, USA.
Adam G ElshaugMelbourne School of Population and Global Health and Melbourne Medical School, The University of Melbourne, Melbourne, Australia.
Joseph S RossDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Daniel J MorganDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Richelle J CooperUCLA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Hyung J ChoDepartment of Quality and Safety, NYC Health and Hospitals, New York, NY, USA.
Jodi B SegalDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Towards Understanding the Patient Experience of Overuse of Medical ResourcesK24AG049036 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEGAL, JODI B. · 2015 to 2024
$1.6M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NIA NIH HHS K24 AG049036
6 · The paper itself

Abstract

Rigorous evidence about the broad range of harms that might be experienced by a patient in the course of testing and treatment is sparse. We aimed to generate recommendations for how researchers might more comprehensively evaluate potential harms of healthcare interventions, to allow clinicians and patients to better include this evidence in clinical decision-making. We propose seven domains of harms of tests and treatments that are relevant to patients: (1) physical impairment, (2) psychological distress, (3) social disruption, (4) disruption in connection to healthcare, (5) labeling, (6) financial impact, and (7) treatment burden. These domains will include a range of severity of harms and variation in timing after testing or treatment, attributable to the service itself or a resulting care cascade. Although some new measures may be needed, diverse data and tools are available to allow the assessment of harms comprehensively across these domains. We encourage researchers to evaluate harms in sub-populations, since the harms experienced may differ importantly by demographics, social determinants, presence of comorbid illness, psychological state, and other characteristics. Regulators, funders, and editors might require either assessment or reporting of harms in each domain or require justification for inclusion and exclusion of different domains.

Identifiers

PMID33479928
PMCPMC8298733

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.