Evidence map›Paper›PMID 33479787›Full record

ArticleAnnals of biomedical engineering2021

Electric Field Stimulation for the Functional Assessment of Isolated Dorsal Root Ganglion Neuron Excitability.

Ian M Berke, Tom M McGrath, J Jordan Stivers, Chang Gui, Marcos N Barcellona, Matthew G Gayoso, Simon Y Tang, Yu-Qing Cao, Munish C Gupta, Lori A Setton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ian M Berke *Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, Campus Box 1097, St. Louis, MO, 63130, USA.ORCID http://orcid.org/0000-0001-5992-4206
Tom M McGrath *Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, Campus Box 1097, St. Louis, MO, 63130, USA.
J Jordan StiversDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Chang GuiDepartment of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, Campus Box 1097, St. Louis, MO, 63130, USA.
Marcos N BarcellonaDepartment of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, Campus Box 1097, St. Louis, MO, 63130, USA.
Matthew G GayosoDepartment of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, Campus Box 1097, St. Louis, MO, 63130, USA.
Simon Y TangDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Yu-Qing CaoDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Munish C GuptaMusculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Lori A SettonDepartment of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, Campus Box 1097, St. Louis, MO, 63130, USA. setton@wustl.edu.
Washington University in St. Louis · US

Funding

Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Alfred Hyoungju Kim · 2018 to 2026
$7.6M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Intervertebral Disc Degeneration and Cross-Talk with the Nervous System - NOSI Diversity SupplementR01AR077678 · NIAMS · WASHINGTON UNIVERSITY · PI SETTON, LORI A., TANG, SIMON YUE-CHEONG · 2020 to 2024
$3.7M
Regulation of Trigeminal Nociception by TRESK ChannelsR01NS103350 · NINDS · WASHINGTON UNIVERSITY · PI CAO, YUQING · 2018 to 2022
$2.5M
The role of physiologic and pathologic AGEs on RAGE signaling in IVD degenerationR01AR074441 · NIAMS · WASHINGTON UNIVERSITY · PI TANG, SIMON YUE-CHEONG · 2019 to 2024
$2.1M
Intra-Articular Delivery of Sustained Release NF-kB Antagonists In ArthritisR01AR070975 · NIAMS · WASHINGTON UNIVERSITY · PI SETTON, LORI A. · 2017 to 2021
$1.7M
Engineering Microenvironments for the Nucleus Pulposus CellR01AR069588 · NIAMS · WASHINGTON UNIVERSITY · PI SETTON, LORI A. · 2016 to 2019
$1.2M
Tissue Level Deformations of the Loaded Spine in Humans with Low Back PainK01AR069116 · NIAMS · WASHINGTON UNIVERSITY · PI TANG, SIMON YUE-CHEONG · 2016 to 2019
$489k
National Science Foundation DGE-1745038NIAMS NIH HHS AR069588NIAMS NIH HHS AR070975NIAMS NIH HHS AR074441NIAMS NIH HHS AR077678NIAMS NIH HHS K01 AR069116NIAMS NIH HHS P30 AR073752NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR069588NIAMS NIH HHS R01 AR070975NIAMS NIH HHS R01 AR074441NIAMS NIH HHS R01 AR077678NINDS NIH HHS R01 NS103350Orthopaedic Research and Education Foundation P20-03413
6 · The paper itself

Abstract

Genetically encoded calcium indicators have proven useful for characterizing dorsal root ganglion neuron excitability in vivo. Challenges persist in achieving high spatial-temporal resolutions in vivo, however, due to deep tissue imaging and motion artifacts that may be limiting technical factors in obtaining measurements. Here we report an ex vivo imaging method, using a peripheral neuron-specific Advillin-GCaMP mouse line and electric field stimulation of dorsal root ganglion tissues, to assess the sensitivity of neurons en bloc. The described method rapidly characterizes Ca

Indexed as

AnimalsCalciumElectric StimulationGanglia, SpinalMice, TransgenicMicroscopy, ConfocalNeuronsTetrodotoxinVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsCalciumTetrodotoxinVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsCalcium imagingDrug screeningGCaMPGECIHigh content imagingNervous system

Identifiers

PMID33479787
PMCPMC8204591
OpenAlexW3124114933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.