ArticleNature cancer2020
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase.
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Article in Nature cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Mass spectrometry-based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta-analysis of individual patient data.Fluids and barriers of the CNS · 2024Pooled it
- Impact of central nervous system involvement in adult patients with Philadelphia-negative acute lymphoblastic leukemia: a GRAALL-2005 study.Haematologica · 2023Trial
- Central nervous system involvement in acute lymphoblastic leukemia: pathogenesis and targeted therapy.Leukemia · 2026Review
- Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity.Nature cancer · 2026Article
- Copper dependency in leukemia metabolism.Nature cancer · 2026Article
- ENO1 promotes acute myeloid leukemia progression through SCD1-mediated lipid metabolism reprogramming.Blood advances · 2026Article
- Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy.Cell death & disease · 2026Review
- Reprogramming lipid metabolism in pediatric cancers.Oncogenesis · 2026Review
- T cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges.The Journal of clinical investigation · 2026Article
- Article
- p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism.Nature genetics · 2026Article
- Metabolic adaptations in cancer progression.Physiological reviews · 2026Review
- Article
- Characteristics and prognosis of central nervous system relapse after allogeneic hematopoietic stem cell transplantation in adult patients with leukemia.Bone marrow transplantation · 2025Article
- Metabolic adaptations of brain metastasis.Nature reviews. Cancer · 2025Review
- Metabolic interplays between the tumour and the host shape the tumour macroenvironment.Nature reviews. Cancer · 2025Review
- Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cerebrospinal fluid attenuates the efficacy of methotrexate against acute lymphoblastic leukemia cells.Blood neoplasia · 2025Article
- Dynamic evolution of TCF3-PBX1 leukemias at the single-cell level under chemotherapy pressure.HemaSphere · 2025Article
- Retinoic acid receptor responder 2 and lipid metabolic reprogramming: A new insight into brain metastasis.Cancer innovation · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 10 institutions in 5 countries.
Angela Maria Savino *Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sara Isabel Fernandes *The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Orianne Olivares *Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Anna ZemlyanskySchneider Children's Medical Center of Israel, Petach Tiqva, Israel.
Antony CousinsWolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-1516-2515
Elke K MarkertWolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Shani BarelFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ifat GeronFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Liron FrishmanFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Yehudit BirgerSheba Medical Center, Ramat Gan, Israel.
Cornelia EckertCharite University, Berlin, Germany.
Sergey TumanovCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-0557-3153
Gillian MacKayCancer Research UK Beatson Institute, Glasgow, UK.
Jurre J KamphorstCancer Research UK Beatson Institute, Glasgow, UK.
Pawel HerzykGlasgow Polyomics, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-7439-292X
Jonatan Fernández-GarcíaThe Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Ifat AbramovichThe Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Inbal MorThe Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.ORCID http://orcid.org/0000-0003-4564-9690
Michela BardiniCentro Ricerca Tettamanti, Fondazione MBBM, Universita degli Studi di Milano-Bicocca, Monza, Italy.
Ersilia BarinMolecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sudha Janaki-RamanDonald B. and Catherine C. Marron Cancer Metabolism Center, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Justin R CrossDonald B. and Catherine C. Marron Cancer Metabolism Center, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael G KharasMolecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eyal GottliebThe Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. e.gottlieb@technion.ac.il.ORCID http://orcid.org/0000-0002-9770-0956
Shai IzraeliFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel. sizraeli@gmail.com.ORCID http://orcid.org/0000-0002-6938-2540
Christina HalseyWolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. chris.halsey@glasgow.ac.uk.ORCID http://orcid.org/0000-0001-5449-5246
Memorial Sloan Kettering Cancer Center · USTechnion – Israel Institute of Technology · ILCancer Research UK Scotland Institute · GBUniversity of Glasgow · GBTel Aviv University · ILCharité - Universitätsmedizin Berlin · DECity Of Hope National Medical Center · USSchneider Children's Medical Center · ILSheba Medical Center · ILUniversity of Milano-Bicocca · IT
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MUncovering the role for MSI2 network in hematopoietic stem cellsR01DK101989 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI Michael Kharas, Vijay Ganesh Sankaran · 2014 to 2026
$6.2MCancer Research UKChief Scientist Office ETM/374NCI NIH HHS P30 CA008748NIDDK NIH HHS R01 DK101989
Abstract
Metabolic reprogramming is a key hallmark of cancer, but less is known about metabolic plasticity of the same tumor at different sites. Here, we investigated the metabolic adaptation of leukemia in two different microenvironments, the bone marrow and the central nervous system (CNS). We identified a metabolic signature of fatty-acid synthesis in CNS leukemia, highlighting Stearoyl-CoA desaturase (
Indexed as
Precursor Cell Lymphoblastic Leukemia-LymphomaStearoyl-CoA DesaturaseCentral Nervous SystemHumansLipogenesisTumor MicroenvironmentStearoyl-CoA Desaturaseacute lymphoblastic leukemiacentral nervous systemfatty acid synthesismetabolic reprogrammingSCD1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.