Evidence map›Paper›PMID 33479697›Full record

ArticleRSC medicinal chemistry2020

Fenretinide binding to the lysosomal protein saposin D alters ceramide solubilization and hydrolysis.

Brandon T Milliken, Lindy Melegari, Gideon L Smith, Kris Grohn, Aaron J Wolfe, Kelsey Moody, Fadi Bou-Abdallah, Robert P Doyle

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Brandon T MillikenDepartment of Chemistry , Syracuse University , Syracuse , NY 13244 , USA . Email: rpdoyle@syr.edu.
Lindy MelegariDepartment of Chemistry , Syracuse University , Syracuse , NY 13244 , USA . Email: rpdoyle@syr.edu.
Gideon L SmithDepartment of Chemistry , State University of New York , Potsdam , NY 13676 , USA . Email: bouabdf@potsdam.edu.
Kris GrohnIchor Therapeutics, Inc , 2521 US-1 , Lafayette , NY 13084 , USA.ORCID 0000-0001-6863-2889
Aaron J WolfeIchor Therapeutics, Inc , 2521 US-1 , Lafayette , NY 13084 , USA.ORCID 0000-0001-5287-8710
Kelsey MoodyIchor Therapeutics, Inc , 2521 US-1 , Lafayette , NY 13084 , USA.
Fadi Bou-AbdallahDepartment of Chemistry , State University of New York , Potsdam , NY 13676 , USA . Email: bouabdf@potsdam.edu.ORCID 0000-0002-8557-1827
Robert P DoyleDepartment of Chemistry , Syracuse University , Syracuse , NY 13244 , USA . Email: rpdoyle@syr.edu.ORCID 0000-0001-6786-5656
iCo Therapeutics (Canada) · CAState University of New York · USSyracuse University · USSUNY Upstate Medical University · US

Funding

Heteropolymer Ferritins Structure-Function StudiesR15GM104879 · NIGMS · STATE UNIVERSITY OF NEW YORK AT POTSDAM · PI BOU-ABDALLAH, FADI · 2015 to 2019
$675k
NIGMS NIH HHS R15 GM104879
6 · The paper itself

Abstract

Fenretinide is a synthetic retinoid pharmaceutical linked to ceramide build-up

Identifiers

PMID33479697
PMCPMC7513591
OpenAlexW3042300815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.