Evidence map›Paper›PMID 33479689›Full record

ArticleRSC medicinal chemistry2020

Synthesis and initial pharmacology of dual-targeting ligands for putative complexes of integrin αVβ3 and PAR2.

Mark W Majewski, Disha M Gandhi, Trudy Holyst, Zhengli Wang, Irene Hernandez, Ricardo Rosas, Jieqing Zhu, Hartmut Weiler, Chris Dockendorff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mark W MajewskiDepartment of Chemistry , Marquette University , P.O. Box 1881 , Milwaukee , WI 53201-1881 , USA . Email: christopher.dockendorff@mu.edu ; Tel: +1 414 288 1617.
Disha M GandhiDepartment of Chemistry , Marquette University , P.O. Box 1881 , Milwaukee , WI 53201-1881 , USA . Email: christopher.dockendorff@mu.edu ; Tel: +1 414 288 1617.
Trudy HolystBlood Research Institute , Versiti , Milwaukee , WI 53226 , USA.
Zhengli WangBlood Research Institute , Versiti , Milwaukee , WI 53226 , USA.
Irene HernandezBlood Research Institute , Versiti , Milwaukee , WI 53226 , USA.
Ricardo RosasDepartment of Chemistry , Marquette University , P.O. Box 1881 , Milwaukee , WI 53201-1881 , USA . Email: christopher.dockendorff@mu.edu ; Tel: +1 414 288 1617.
Jieqing ZhuBlood Research Institute , Versiti , Milwaukee , WI 53226 , USA.
Hartmut WeilerBlood Research Institute , Versiti , Milwaukee , WI 53226 , USA.
Chris DockendorffDepartment of Chemistry , Marquette University , P.O. Box 1881 , Milwaukee , WI 53201-1881 , USA . Email: christopher.dockendorff@mu.edu ; Tel: +1 414 288 1617.ORCID 0000-0002-4092-5636
Marquette University · USVersiti Blood Center of Wisconsin · USMedical College of Wisconsin · US

Funding

Structural Transition of Cellular Integrins and Applications ThereofR01HL131836 · NHLBI · VERSITI WISCONSIN, INC. · PI Jieqing Zhu · 2016 to 2026
$5.5M
Regulation of Innate Immunity by Coagulation ReceptorsR01HL133348 · NHLBI · VERSITI WISCONSIN, INC. · PI WEILER, HARTMUT KARL-HEINZ · 2016 to 2019
$1.7M
Structural Mechanisms Underlying the Activity Regulation of the Receptor-like Protein Tyrosine Phosphatase, CD148/PTPRJR01GM137143 · NIGMS · VERSITI WISCONSIN, INC. · PI ZHU, JIEQING · 2020 to 2023
$1.4M
Novel Approaches to the Modulation of Protease-Activated Receptor (PAR) SignalingR15HL127636 · NHLBI · MARQUETTE UNIVERSITY · PI DOCKENDORFF, CHRISTOPHER · 2015 to 2020
$903k
NHLBI NIH HHS R01 HL131836NHLBI NIH HHS R01 HL133348NHLBI NIH HHS R15 HL127636NIGMS NIH HHS R01 GM137143
6 · The paper itself

Abstract

Unpublished data from our labs led us to hypothesize that activated protein C (aPC) may initiate an anti-inflammatory signal in endothelial cells by modulating both the integrin αVβ3 and protease-activated receptor 2 (PAR2), which may exist in close proximity on the cellular surface. To test this hypothesis and to probe the possible inflammation-related pathway, we designed and synthesized dual-targeting ligands composed of modified versions of two αVβ3 ligands and two agonists of PAR2. These novel ligands were connected

Identifiers

PMID33479689
PMCPMC7496306
OpenAlexW3041418040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.