Evidence map›Paper›PMID 33479638›Full record

ArticleRSC medicinal chemistry2020

Structure-activity relationships of sulfonamides derived from carvacrol and their potential for the treatment of Alzheimer's disease.

Márcia Maria de Souza, Marina Corrêa Andreolla, Thaís Cecília Ribeiro, Ana Elisa Gonçalves, Alex Rogério Medeiros, Anacleto Silva de Souza, Leonardo Luiz Gomes Ferreira, Adriano Defini Andricopulo, Rosendo Augusto Yunes, Aldo Sena de Oliveira

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Sulfonamide Derivatives: Recent Compounds with Potent Anti-alzheimer's Disease Activity.Central nervous system agents in medicinal chemistry · 2024
    Review
  5. Antioxidants (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Márcia Maria de SouzaSchool of Health Sciences/Graduate Program in Pharmaceutical Sciences , UNIVALI , Rua Uruguai, 458 F6 lab 206 Campus I, centro , Itajai , SC 88302-202 , Brazil.
Marina Corrêa AndreollaSchool of Health Sciences/Graduate Program in Pharmaceutical Sciences , UNIVALI , Rua Uruguai, 458 F6 lab 206 Campus I, centro , Itajai , SC 88302-202 , Brazil.
Thaís Cecília RibeiroSchool of Health Sciences/Graduate Program in Pharmaceutical Sciences , UNIVALI , Rua Uruguai, 458 F6 lab 206 Campus I, centro , Itajai , SC 88302-202 , Brazil.
Ana Elisa GonçalvesSchool of Health Sciences/Graduate Program in Pharmaceutical Sciences , UNIVALI , Rua Uruguai, 458 F6 lab 206 Campus I, centro , Itajai , SC 88302-202 , Brazil.
Alex Rogério MedeirosLaboratory of Medicinal and Computational Chemistry , Center for Research and Innovation in Biodiversity and Drug Discovery , Institute of Physics of São Carlos , University of Sao Paulo , Av. João Dagnone, 1100 - Santa Angelina , São Carlos , SP 13563-120 , Brazil.
Anacleto Silva de SouzaLaboratory of Medicinal and Computational Chemistry , Center for Research and Innovation in Biodiversity and Drug Discovery , Institute of Physics of São Carlos , University of Sao Paulo , Av. João Dagnone, 1100 - Santa Angelina , São Carlos , SP 13563-120 , Brazil.
Leonardo Luiz Gomes FerreiraLaboratory of Medicinal and Computational Chemistry , Center for Research and Innovation in Biodiversity and Drug Discovery , Institute of Physics of São Carlos , University of Sao Paulo , Av. João Dagnone, 1100 - Santa Angelina , São Carlos , SP 13563-120 , Brazil.
Adriano Defini AndricopuloLaboratory of Medicinal and Computational Chemistry , Center for Research and Innovation in Biodiversity and Drug Discovery , Institute of Physics of São Carlos , University of Sao Paulo , Av. João Dagnone, 1100 - Santa Angelina , São Carlos , SP 13563-120 , Brazil.
Rosendo Augusto YunesDepartment of Chemistry , Federal University of Santa Catarina , R. Eng. Agronômico Andrei Cristian Ferreira, s/n - Trindade , Florianópolis , SC 88040-900 , Brazil.
Aldo Sena de OliveiraLaboratory of Medicinal and Computational Chemistry , Center for Research and Innovation in Biodiversity and Drug Discovery , Institute of Physics of São Carlos , University of Sao Paulo , Av. João Dagnone, 1100 - Santa Angelina , São Carlos , SP 13563-120 , Brazil.ORCID 0000-0001-7760-4484
Universidade de São Paulo · BRDepartment of Health · IEUniversidade Federal de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Five synthetic sulfonamides derived from carvacrol, a natural product and a small molecule with druglike properties, were evaluated with respect to their effects on the cognitive deficits of animals with streptozotocin (STZ)-induced Alzheimer's disease (AD). Memory, ambulation, anxiety and oxidative stress were evaluated.

Identifiers

PMID33479638
PMCPMC7429979
OpenAlexW3005831516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.