Evidence map›Paper›PMID 33479628›Full record

ArticleRSC medicinal chemistry2020

The effect of polar headgroups and spacer length on the DNA transfection of cholesterol-based cationic lipids.

Widchaya Radchatawedchakoon, Chopaka Thongbamrer, Wuttiphong Konbamrung, Phakamas Khattawee, Uthai Sakee, Wanlapa Roobsoong, Jetsumon Sattabongkot, Praneet Opanasopit, Boon-Ek Yingyongnarongkul

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In one paragraph

Article in RSC medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Widchaya RadchatawedchakoonCreative Chemistry and Innovation Research Unit , Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC) , Faculty of Science , Mahasarakham University , Maha Sarakham , 44150 , Thailand . Email: widchaya.r@msu.ac.th ; Email: widchaya@hotmail.com ; ; Tel: +66 43 754246.ORCID 0000-0002-2565-2908
Chopaka ThongbamrerDepartment of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC) , Faculty of Science , Ramkhamhaeng University , Bangkok , 10240 , Thailand.
Wuttiphong KonbamrungCreative Chemistry and Innovation Research Unit , Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC) , Faculty of Science , Mahasarakham University , Maha Sarakham , 44150 , Thailand . Email: widchaya.r@msu.ac.th ; Email: widchaya@hotmail.com ; ; Tel: +66 43 754246.
Phakamas KhattaweeDepartment of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC) , Faculty of Science , Ramkhamhaeng University , Bangkok , 10240 , Thailand.
Uthai SakeeCreative Chemistry and Innovation Research Unit , Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC) , Faculty of Science , Mahasarakham University , Maha Sarakham , 44150 , Thailand . Email: widchaya.r@msu.ac.th ; Email: widchaya@hotmail.com ; ; Tel: +66 43 754246.
Wanlapa RoobsoongMahidol Vivax Research Unit , Faculty of Tropical Medicine , Mahidol University , Bangkok , 10400 , Thailand.ORCID 0000-0002-1789-0439
Jetsumon SattabongkotMahidol Vivax Research Unit , Faculty of Tropical Medicine , Mahidol University , Bangkok , 10400 , Thailand.
Praneet OpanasopitPharmaceutical Development of Green Innovations Group (PDGIG) , Faculty of Pharmacy , Silpakorn University , Nakhon Pathom , 73000 , Thailand.
Boon-Ek YingyongnarongkulDepartment of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC) , Faculty of Science , Ramkhamhaeng University , Bangkok , 10240 , Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article is related to the effects of the headgroups and spacer length of cationic lipids on transfection efficiency. To develop highly potent cationic lipids, a series of divalent lysine-diamine conjugated cholesterol-based cationic lipids with three different headgroups (ammonium, trimethyl ammonium, and guanidinium) were synthesized. The newly synthesized cationic lipids (

Identifiers

PMID33479628
PMCPMC7484938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.