Evidence map›Paper›PMID 33479621›Full record

ArticleRSC medicinal chemistry2020

Identification of 6-amino-1

Michael G Thomas, Manu De Rycker, Myriam Ajakane, Sabrinia D Crouch, Lorna Campbell, Alain Daugan, Gloria Fra, César Guerrero, Claire J Mackenzie, Lorna MacLean and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Michael G ThomasDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.ORCID 0000-0003-0377-0281
Manu De RyckerDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.ORCID 0000-0002-3171-3519
Myriam AjakaneCentre de Recherche , GlaxoSmithKline , Les Ulis, 25,27 Avenue du Quebec , 91140 Villebon sur Yvette , France.
Sabrinia D CrouchGlobal Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2, 28760 Tres Cantos , Madrid , Spain . Email: tim.j.miles@gsk.com.
Lorna CampbellDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Alain DauganCentre de Recherche , GlaxoSmithKline , Les Ulis, 25,27 Avenue du Quebec , 91140 Villebon sur Yvette , France.
Gloria FraGalChimia S.A. , Cebreiro s/n, 15823, O Pino , A Coruña , Spain.
César GuerreroGalChimia S.A. , Cebreiro s/n, 15823, O Pino , A Coruña , Spain.
Claire J MackenzieDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Lorna MacLeanDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Sujatha ManthriDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Franck MartinCentre de Recherche , GlaxoSmithKline , Les Ulis, 25,27 Avenue du Quebec , 91140 Villebon sur Yvette , France.
Suzanne NorvalDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Maria Osuna-CabelloDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Jennifer RileyDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Yoko ShishikuraDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Juan Miguel-SilesGlobal Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2, 28760 Tres Cantos , Madrid , Spain . Email: tim.j.miles@gsk.com.
Frederick R C SimeonsDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Laste StojanovskiDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
John ThomasDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Stephen ThompsonDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Raul F VelascoGalChimia S.A. , Cebreiro s/n, 15823, O Pino , A Coruña , Spain.
Jose M FiandorGlobal Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2, 28760 Tres Cantos , Madrid , Spain . Email: tim.j.miles@gsk.com.
Paul G WyattDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Kevin D ReadDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Ian H GilbertDrug Discovery Unit , Wellcome Centre for Anti-Infectives Research , Division of Biological Chemistry and Drug Discovery , School of Life Sciences , University of Dundee , Dundee DD1 5EH , UK . Email: I.H.Gilbert@dundee.ac.uk.
Timothy J MilesGlobal Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2, 28760 Tres Cantos , Madrid , Spain . Email: tim.j.miles@gsk.com.ORCID 0000-0001-7407-7404

Funding

Wellcome Trust 203134/Z/16/ZWellcome Trust 204672/Z/16/Z
6 · The paper itself

Abstract

Visceral leishmaniasis (VL) affects millions of people across the world, largely in developing nations. It is fatal if left untreated and the current treatments are inadequate. As such, there is an urgent need for new, improved medicines. In this paper, we describe the identification of a 6-amino-

Identifiers

PMID33479621
PMCPMC7651859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.