Evidence map›Paper›PMID 33479608›Full record

ArticleRSC medicinal chemistry2020

Discovery of isoxazolyl-based inhibitors of

Shams Ul Mahmood, Huimin Cheng, Sreedhar R Tummalapalli, Ramappa Chakrasali, Rammohan R Yadav Bheemanaboina, Tamara Kreiss, Agnieska Chojnowski, Tyler Eck, John J Siekierka, David P Rotella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Discovery of Imidazole-Based Inhibitors ofACS medicinal chemistry letters · 2021
    Article
  4. Review
  5. Frontiers in microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shams Ul MahmoodDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
Huimin ChengDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
Sreedhar R TummalapalliDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
Ramappa ChakrasaliDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
Rammohan R Yadav BheemanaboinaDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
Tamara KreissDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
Agnieska ChojnowskiDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
Tyler EckDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
John J SiekierkaDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
David P RotellaDepartment of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.ORCID 0000-0002-8224-218X

Funding

Development of inhibitors of P. falciparum cGMP dependent protein kinase (PfPKG) for malaria chemopreventionR01AI133633 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI BHANOT, PURNIMA, ROTELLA, DAVID · 2017 to 2019
$2.1M
NIAID NIH HHS R01 AI133633
6 · The paper itself

Abstract

The cGMP-dependent protein kinase in

Identifiers

PMID33479608
PMCPMC7536641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.