ArticleOncogene2021
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
Open access · greenAbstract read
In one paragraph
Article in Oncogene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
What it found
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Who cites it
55 citing papers in PubMed, 80 citations in OpenAlex.
- Review
- Succinylation related gene signature enables risk stratification and prognostic modeling in breast cancer patients.Amino acids · 2026Article
- Adipocyte-rich microenvironment promotes TNBC progression through SIRT6-associated ACSL5 dysregulation and lipid storage-associated phenotypes.Journal of experimental & clinical cancer research : CR · 2026Article
- Metabolites as signalling molecules in the tumour immune microenvironment.Nature reviews. Immunology · 2026Review
- Beyond deacetylation: crosstalk mechanisms and context-dependent regulation of sirtuin non-classical enzymatic functions in disease.Molecular medicine (Cambridge, Mass.) · 2026Review
- SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth.bioRxiv : the preprint server for biology · 2026Article
- Succinylation: A Functional Nexus Between Metabolic Reprogramming and Epigenetic Modifications in Cancer.Molecules (Basel, Switzerland) · 2026Review
- Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors.Cell communication and signaling : CCS · 2026Review
- Generation of High-Quality Succinyl Spectral Libraries for Improved Proteome-Wide Succinylome Analysis Using Data-Independent Acquisition.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Succinylation in cancer immunotherapy: mechanisms, biomarkers, and therapeutic implications.Frontiers in immunology · 2026Review
- A Combined SIRT5 Activation and SIRT3 Inhibition Prevents Breast Cancer Spheroids Growth by Reducing HIF-1α and Mitophagy.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Sirtuins in Women's Health.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Post-translational acylation of proteins in cardiac hypertrophy.Nature reviews. Cardiology · 2025Review
- Sirtuins as Therapeutic Targets for Treating Cancer, Metabolic Diseases, and Neurodegenerative Diseases.Pharmaceuticals (Basel, Switzerland) · 2025Review
- SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence.Communications biology · 2025Article
- Lysine malonylation as a therapeutic target: implications for metabolic, inflammatory, and oncological disorders.Amino acids · 2025Review
- The role of succinylation-mediated metabolic reprogramming in tumor progression.Molecular biology reports · 2025Review
- Regulators of Cancer Progression: Succinylation.Cancers · 2025Review
- Histone acetylation modulators in breast cancer.Breast cancer research : BCR · 2025Review
- SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1.Nature metabolism · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 3 countries.
Yashira L Negrón Abril *Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.ORCID http://orcid.org/0000-0002-5922-9999
Irma R Fernandez *Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.
Jun Young HongDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.ORCID http://orcid.org/0000-0002-5257-6525
Ying-Ling ChiangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.ORCID http://orcid.org/0000-0001-5591-6209
Dennis A KutateladzeDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Qingjie ZhaoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Min YangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Jing HuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Sushabhan SadhukhanDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Bo LiDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Bin HeDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Brenna RemickDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.
Jessica Jingyi BaiDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
James MullmannDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.
Fangyu WangDepartment of Molecular Medicine, Cornell University, Ithaca, NY, 14853, USA.
Viviana MaymiDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.
Ravi DhawanDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.
Johan AuwerxLaboratory for Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
Teresa SouthardDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.
Richard A CerioneDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Hening LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA. hl379@cornell.edu.ORCID http://orcid.org/0000-0002-0255-2701
Robert S WeissDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA. rsw26@cornell.edu.ORCID http://orcid.org/0000-0003-3327-1379
Cornell University · USÉcole Polytechnique Fédérale de Lausanne · CHGuiyang Medical University · CNHoward Hughes Medical Institute · US
Funding
PREDOCTORAL TRAINING IN CELLULAR AND MOLECULAR BIOLOGYT32GM007273 · NIGMS · CORNELL UNIVERSITY ITHACA · PI BRETSCHER, ANTHONY P. · 1985 to 2019
$11.6MCHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4MSuccinylation and Malonylation as Novel Protein Modifications in CancerR01CA163255 · NCI · CORNELL UNIVERSITY · PI CERIONE, RICHARD A., LIN, HENING · 2011 to 2015
$2.9MTargeting the dependency of cancer cells on the sirtuin SIRT5R01CA223534 · NCI · CORNELL UNIVERSITY · PI CERIONE, RICHARD A., LIN, HENING · 2019 to 2023
$2.3MElucidating the tumor suppressive effects of the sirtuin, SIRT1, in triple-negative breast cancerF30CA250451 · NCI · CORNELL UNIVERSITY · PI MULLMANN, JAMES · 2020 to 2024
$234kNCI NIH HHS F30 CA250451NCI NIH HHS R01 CA163255NCI NIH HHS R01 CA223534NIGMS NIH HHS T32 GM007273NIGMS NIH HHS T32 GM008500
Abstract
SIRT5 is a member of the sirtuin family of NAD
Indexed as
AnimalsBreast NeoplasmsCell Line, TumorEnzyme InhibitorsFemaleHeterograftsHumansIsocitrate DehydrogenaseMiceMice, KnockoutOxidative StressReactive Oxygen SpeciesSirtuinsEnzyme InhibitorsIDH2 protein, humanIsocitrate DehydrogenaseReactive Oxygen SpeciesSIRT5 protein, humanSIRT5 protein, mouseSirtuins
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