ArticleCommunications biology2021
A cross-species assessment of behavioral flexibility in compulsive disorders.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Touchscreen and Translational Cognition: A Systematic Review of Trials in Humans and Rodents.Journal of neurochemistry · 2025Pooled it
- The genetics of trichotillomania and excoriation disorder: A systematic review.Comprehensive psychiatry · 2024Pooled it
- Characterisation of a touchscreen-based task for assessing cognitive judgement bias in mice: a new translational tool for affective state disorder drug screening.Psychopharmacology · 2026Article
- Male Sapap3 knockout mice show threat bias under conflict during platform-mediated avoidance task: effects of extinction with response prevention and implications for obsessive compulsive disorder.Translational psychiatry · 2026Article
- Reward contingency reorganizes lateral orbitofrontal cortex pyramidal neuron activity from reward-aligned to action-aligned during associative learning.Frontiers in cellular neuroscience · 2026Article
- Late development of OCD-like phenotypes in Dlgap1 knockout mice.Psychopharmacology · 2025Article
- Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model.Nature communications · 2023Article
- Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species.Cell & bioscience · 2023Article
- Open science and data sharing in cognitive neuroscience with MouseBytes and MouseBytes.Scientific data · 2023Article
- The Sapap3Translational psychiatry · 2023Article
- SAPAP3, SPRED2, and obsessive-compulsive disorder: the search for fundamental phenotypes.Frontiers in molecular neuroscience · 2023Article
- Body Focused Repetitive Behavior Disorders: Behavioral Models and Neurobiological Mechanisms.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2023Review
- Review
- The prefrontal cortex and OCD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Association of Environmental Uncertainty With Altered Decision-making and Learning Mechanisms in Youths With Obsessive-Compulsive Disorder.JAMA network open · 2021Article
- En route to precision medicine for mental health: World Mental Health Day 2021.Communications biology · 2021Article
- Psychiatric symptoms influence reward-seeking and loss-avoidance decision-making through common and distinct computational processes.Psychiatry and clinical neurosciences · 2021Article
- Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lack of behavioral flexibility has been proposed as one underlying cause of compulsions, defined as repetitive behaviors performed through rigid rituals. However, experimental evidence has proven inconsistent across human and animal models of compulsive-like behavior. In the present study, applying a similarly-designed reversal learning task in two different species, which share a common symptom of compulsivity (human OCD patients and Sapap3 KO mice), we found no consistent link between compulsive behaviors and lack of behavioral flexibility. However, we showed that a distinct subgroup of compulsive individuals of both species exhibit a behavioral flexibility deficit in reversal learning. This deficit was not due to perseverative, rigid behaviors as commonly hypothesized, but rather due to an increase in response lability. These cross-species results highlight the necessity to consider the heterogeneity of cognitive deficits in compulsive disorders and call for reconsidering the role of behavioral flexibility in the aetiology of compulsive behaviors.
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