Evidence map›Paper›PMID 33479472›Full record

ArticleScientific reports2021

The relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia in children.

Ping Chen, Zheng Huang, Lumin Chen, Shihao Zhuang, Hongli Lin, Jianfeng Xie, Kuicheng Zheng

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Risk factors for refractoryFrontiers in pediatrics · 2025
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  7. Exploring Clinical Characteristics and Risk Factors ofJournal of inflammation research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ping ChenFujian Children's Hospital, Fujian, China. 919958089@qq.com.
Zheng HuangFujian Center for Disease Control and Prevention, Fujian, China.
Lumin ChenFujian Maternity and Child Health Hospital, Fujian, China. clm2020@yeah.net.
Shihao ZhuangFujian Children's Hospital, Fujian, China.
Hongli LinFujian Maternity and Child Health Hospital, Fujian, China.
Jianfeng XieFujian Center for Disease Control and Prevention, Fujian, China.
Kuicheng ZhengFujian Center for Disease Control and Prevention, Fujian, China.
Fuzhou Maternity and Child Health Care Hospital · CNFujian Women and Children Hospital · CN

Funding

National Science and Technology Major Project 2017ZX10103008
6 · The paper itself

Abstract

To investigate the relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia (RMPP) in children. Serum levels of LncRNA NNT-AS1 of RMPP and non-RMPP (NRMPP) patients were detected by real-time PCR, and were analyzed together with serum c-reactive protein (CRP) and procalcitonin (PCT). Correlations between LncRNA NNT-AS1 and CRP and PCT were analyzed by Pearson correlation test. The ROC curve was used to analyze the potential of LncRNA NNT-AS1, CRP and PCT as biomarkers for predicting RMPP. Logistic regression crossover model and the Excel compiled by Andersson et al. were used to analyze the interactions among the biomarkers. We found that LncRNA NNT-AS1, CRP and PCT were all highly expressed in patients with RMPP. LncRNA NNT-AS1 could positively correlate with the expressions of CRP and PCT, and jointly promote the occurrence of RMPP. The combined diagnosis of LncRNA NNT-AS1, CRP and PCT could predict the occurrence of RMPP.

Indexed as

BiomarkersChildChild, PreschoolC-Reactive ProteinFemaleHumansLogistic ModelsMaleMycoplasma pneumoniaePneumonia, MycoplasmaProcalcitoninRNA, Long NoncodingBiomarkersC-Reactive ProteinProcalcitoninRNA, Long Noncoding

Identifiers

PMID33479472
PMCPMC7820231
OpenAlexW3122106461

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.