ArticleScientific reports2021
Neonicotinoids disrupt memory, circadian behaviour and sleep.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Methylene Blue Alleviates Thiamethoxam-Induced Toxicity in Honeybee Larvae by Activating Dihydrolipoyl Dehydrogenase.Insects · 2026Article
- Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model.Journal of applied toxicology : JAT · 2026Article
- Review
- Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model.Scientific reports · 2025Article
- BioClocks UK: driving robust cycles of discovery to impact.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Exposure to neonicotinoid pesticides induces physiological disorders and affects color performance and foraging behavior in goldfish.Physiological reports · 2024Article
- Avian migration clocks in a changing world.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Unravelling nicotinic receptor and ligand features underlying neonicotinoid knockdown actions on the malaria vector mosquitoOpen biology · 2024Article
- Exploring neonicotinoid effects onFrontiers in physiology · 2024Article
- Critical roles of nicotinic acetylcholine receptors in olfactory memory formation and retrieval in crickets.Frontiers in physiology · 2024Article
- Identification of CYCLE targets that contribute diverse features of circadian rhythms in the mosquito Culex pipiens.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2023Article
- Article
- A neonicotinoid pesticide alters Drosophila olfactory processing.Scientific reports · 2023Article
- On-Site Detection of Neonicotinoid Pesticides Using Functionalized Gold Nanoparticles and Halogen Bonding.ACS applied nano materials · 2023Article
- Chronic larval exposure to thiacloprid impairs honeybee antennal selectivity, learning and memory performances.Frontiers in physiology · 2023Article
- The Synergistic Effect of Thiamethoxam and Synapsin dsRNA Targets Neurotransmission to Induce Mortality inInternational journal of molecular sciences · 2022Article
- DYRK1a Inhibitor Mediated Rescue ofFrontiers in pharmacology · 2022Article
- Dynamically expressed single ELAV/Hu orthologue elavl2 of bees is required for learning and memory.Communications biology · 2021Article
- Effects of Insecticides and Microbiological Contaminants onMolecules (Basel, Switzerland) · 2021Review
- Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp,Insects · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Globally, neonicotinoids are the most used insecticides, despite their well-documented sub-lethal effects on beneficial insects. Neonicotinoids are nicotinic acetylcholine receptor agonists. Memory, circadian rhythmicity and sleep are essential for efficient foraging and pollination and require nicotinic acetylcholine receptor signalling. The effect of field-relevant concentrations of the European Union-banned neonicotinoids: imidacloprid, clothianidin, thiamethoxam and thiacloprid were tested on Drosophila memory, circadian rhythms and sleep. Field-relevant concentrations of imidacloprid, clothianidin and thiamethoxam disrupted learning, behavioural rhythmicity and sleep whilst thiacloprid exposure only affected sleep. Exposure to imidacloprid and clothianidin prevented the day/night remodelling and accumulation of pigment dispersing factor (PDF) neuropeptide in the dorsal terminals of clock neurons. Knockdown of the neonicotinoid susceptible Dα1 and Dβ2 nicotinic acetylcholine receptor subunits in the mushroom bodies or clock neurons recapitulated the neonicotinoid like deficits in memory or sleep/circadian behaviour respectively. Disruption of learning, circadian rhythmicity and sleep are likely to have far-reaching detrimental effects on beneficial insects in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.