Evidence map›Paper›PMID 33479373›Full record

ArticleScientific reports2021

Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle.

Josephine F Reijneveld, Mira Holzheimer, David C Young, Kattya Lopez, Sara Suliman, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B Murray, Eri Ishikawa and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Asymmetric Total Synthesis and Structural Revision of DATAngewandte Chemie (International ed. in English) · 2024
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Josephine F ReijneveldDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.
Mira HolzheimerStratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
David C YoungDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.
Kattya LopezDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.
Sara SulimanDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.
Judith JimenezSocios En Salud, Lima, Peru.
Roger CalderonSocios En Salud, Lima, Peru.
Leonid LeccaSocios En Salud, Lima, Peru.
Megan B MurrayDivision of Global Health Equity, Department of Global Health and Social Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Eri IshikawaDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Sho YamasakiDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Adriaan J MinnaardStratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
D Branch MoodyDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.
Ildiko Van RhijnDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA. i.vanrhijn@uu.nl.
EsSALUD · PEBrigham and Women's Hospital · USHarvard University · USOsaka University · JPUniversity of Groningen · NLUtrecht University · NL

Funding

Metabolomics Core U19AI111224 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MURRAY, MEGAN, MURRAY, MEGAN B · 2015 to 2021
$20.4M
T cell response to CDI-restricted lipids in tuberculosisR01AI049313 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2001 to 2025
$10.6M
Nederlandse Organisatie voor Wetenschappelijk Onderzoek Toppunt 15.002NIAID NIH HHS R01 AI049313NIAID NIH HHS U19 AI111224NIH HHS U19 AI111224
6 · The paper itself

Abstract

The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of mycobacterial diacyltrehalose (DAT) that differ in their fatty acid composition, DAT

Indexed as

Antigen-Presenting CellsAntigens, CD1Host-Pathogen InteractionsHumansInterferon-gammaLectins, C-TypeLipidsMycobacterium tuberculosisReceptors, Antigen, T-CellT-LymphocytesTrehaloseTuberculosisAntigens, CD1CD1b antigenIFNG protein, humanInterferon-gammaLectins, C-TypeLipidsReceptors, Antigen, T-CellTrehalose

Identifiers

PMID33479373
PMCPMC7820438
OpenAlexW3123139433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.