ArticleScientific reports2021
Further evidence supporting a potential role for ADH1B in obesity.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.Nature genetics · 2023Pooled it
- Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.Cancer medicine · 2023Pooled it
- ACADL and ADH1B signify ketone body metabolic reprogramming in osteoarthritic synovium: insights from bioinformatics and animal model studies.Frontiers in medicine · 2026Article
- Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity.Obesity (Silver Spring, Md.) · 2026Article
- Personalized prediction of esophageal cancer risk based on virtually generated alcohol data.Journal of translational medicine · 2025Article
- Network Mendelian randomisation analysis deciphers protein pathways linking type 2 diabetes and gastrointestinal disease.Diabetes, obesity & metabolism · 2025Article
- Fatty acid metabolism influences the immune microenvironment in papillary thyroid cancer and identifies SCD as a novel biomarker.Frontiers in endocrinology · 2025Article
- Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels.Communications biology · 2024Article
- Article
- Adipocytes impact on gastric cancer progression: Prognostic insights and molecular features.World journal of gastrointestinal oncology · 2024Article
- ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Study on Potential Differentially Expressed Genes in Idiopathic Pulmonary Fibrosis by Bioinformatics and Next-Generation Sequencing Data Analysis.Biomedicines · 2023Article
- Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models.Scientific data · 2023Article
- Article
- Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer.British journal of cancer · 2023Article
- Efficacy of Low-Dose Aspirin in Colorectal Cancer Risk Prevention is Dependent onCancer research communications · 2022Article
- The Combined Partial Knockdown ofAntioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 8 institutions in 2 countries.
Liza D MoralesSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA. liza.morales@utrgv.edu.ORCID 0000-0003-1056-9121
Douglas T CromackSouth Texas Veterans Health Care System, San Antonio, TX, USA.
Devjit TripathySouth Texas Veterans Health Care System, San Antonio, TX, USA.
Marcel FourcaudotDepartment of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Satish KumarSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA.ORCID 0000-0002-1969-4431
Joanne E CurranSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA.
Melanie CarlessDepartment of Population Health, Texas Biomedical Research Institute, San Antonio, TX, USA.
Harald H H GöringSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA.
Shirley L HuUniversity of Texas Health Houston, School of Public Health, Brownsville, TX, USA.
Juan Carlos Lopez-AlvarengaSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA.ORCID 0000-0002-0966-8766
Kristina M GarskeDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-7228-8125
Päivi PajukantaDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-6423-8056
Kerrin S SmallKing's College London, London, UK.ORCID 0000-0003-4566-0005
Craig A GlastonburyKing's College London, London, UK.ORCID 0000-0001-5542-2225
Swapan K DasInternal Medicine-Endocrinology and Metabolism, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-2197-8855
Carl LangefeldDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-4266-6949
Robert L HansonPhoenix Epidemiology and Clinical Research Branch, NIDDK, Phoenix, AZ, USA.ORCID 0000-0002-4252-7068
Wen-Chi HsuehPhoenix Epidemiology and Clinical Research Branch, NIDDK, Phoenix, AZ, USA.
Luke NortonDepartment of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Rector AryaSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA.
Srinivas MummidiSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA.ORCID 0000-0002-4068-6380
John BlangeroSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA.ORCID 0000-0001-6250-5723
Ralph A DeFronzoSouth Texas Veterans Health Care System, San Antonio, TX, USA.
Ravindranath DuggiralaSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA.
Christopher P JenkinsonSouth Texas Diabetes and Obesity Institute Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg/Harlingen/Brownsville, TX, USA. christopher.jenkinson@utrgv.edu.ORCID 0000-0002-1862-4714
The University of Texas Rio Grande Valley · USThe University of Texas Health Science Center at San Antonio · USKing's College London · GBPhoenix (United States) · USUniversity of California, Los Angeles · USWake Forest University · USTexas Biomedical Research Institute · USThe University of Texas Health Science Center at Houston · US
Funding
Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 1985 to 2019
$50.2MInstitute for Integration of Medicine & Science: A Partnership to Improve HealthUM1TR004538 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ROBERT A CLARK, Kenneth M Hargreaves · 2023 to 2026
$22.3MInstitute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR002645 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2018 to 2022
$20.4MMolecular Profiling of Diabetes and its ComplicationsZIADK075071 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HANSON, ROBERT · 2012 to 2025
$7.4MQuantitative Trait Locus Mapping in Human PedigreesR37MH059490 · NIMH · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BLANGERO, JOHN · 2001 to 2010
$6.8MGenomics of dyslipidemia in MexicansR01HL095056 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAJUKANTA, PAIVI · 2009 to 2018
$5.9MMapping Diabetes Susceptibility by Expression Traits in African AmericansR01DK090111 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAS, SWAPAN KUMAR · 2011 to 2015
$2.5MIdentification of Prediabetes Genes by Expression Linkage AnalysisR01DK079195 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JENKINSON, CHRISTOPHER P · 2008 to 2013
$2.5MGENETICS OF GALLBLADDER DISEASE IN MEXICAN AMERICANSR01DK053889 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI DUGGIRALA, RAVINDRANATH · 1998 to 2011
$2.3MFunctional genetic variants for type 2 diabetesU01DK105561 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOHLKE, KAREN L. · 2015 to 2019
$2.3MDiabesity Gene Discovery at Chromosome 6q23R01DK067690 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JENKINSON, CHRISTOPHER P · 2004 to 2008
$2.3MGenetics of Birth Weight in Mexican AmericansR01HD041111 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI DUGGIRALA, RAVINDRANATH · 2001 to 2005
$1.9MMedical Research Council MR/L01999X/1NCATS NIH HHS UL1 TR002645NCATS NIH HHS UM1 TR004538NHLBI NIH HHS F31 HL142180NHLBI NIH HHS P01 HL028481NHLBI NIH HHS R01 HL095056NICHD NIH HHS R01 HD041111NIDDK NIH HHS R01 DK053889NIDDK NIH HHS R01 DK067690NIDDK NIH HHS R01 DK079195NIDDK NIH HHS R01 DK090111NIDDK NIH HHS U01 DK105561NIMH NIH HHS R01 MH059490NIMH NIH HHS R37 MH059490
Abstract
Insulin is an essential hormone that regulates glucose homeostasis and metabolism. Insulin resistance (IR) arises when tissues fail to respond to insulin, and it leads to serious health problems including Type 2 Diabetes (T2D). Obesity is a major contributor to the development of IR and T2D. We previously showed that gene expression of alcohol dehydrogenase 1B (ADH1B) was inversely correlated with obesity and IR in subcutaneous adipose tissue of Mexican Americans. In the current study, a meta-analysis of the relationship between ADH1B expression and BMI in Mexican Americans, African Americans, Europeans, and Pima Indians verified that BMI was increased with decreased ADH1B expression. Using established human subcutaneous pre-adipocyte cell lines derived from lean (BMI < 30 kg m
Indexed as
AdipocytesAdipose TissueAdultAgedAged, 80 and overAlcohol DehydrogenaseBody Mass IndexDiabetes Mellitus, Type 2HumansInsulinInsulin ResistanceMexican AmericansMiddle AgedObesitySubcutaneous FatADH1B protein, humanAlcohol DehydrogenaseInsulin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.