Trial reportScientific reports2021
Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02784821 (Antibiotic Effects on the Developing Microbiome, Metabolome and Morbidities in Preterm Neonates), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antibiotic Effects on the Developing Microbiome, Metabolome and Morbidities in Preterm Neonates
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Discontinuation of empirical antibiotics in suspected neonatal early-onset sepsis: a systematic review and meta-analysis.Pediatric research · 2026Pooled it
- The effect of antibiotics on the intestinal microbiota in children - a systematic review.Frontiers in allergy · 2024Pooled it
- The impact of neonatal intensive care unit antibiotics on gut bacterial microbiota of preterm infants: a systematic review.Frontiers in microbiomes · 2023Pooled it
- Early gut microbiome composition of very preterm infants randomised to receive human milk volumes of 60 ml/kg/day or more within the first 36 hours after birth.Pediatric research · 2026Trial
- Effect of early antibiotic exposure on necrotizing enterocolitis and growth in extremely preterm infants.Pediatric research · 2025Trial
- Trial
- Risk assessment of early-onset sepsis in extremely preterm infants: implications for antibiotic stewardship.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Single-cell detection and quantification of the microbiota by MicFLY.Cell host & microbe · 2026Article
- Gut dysbiosis associated with neonatal respiratory distress syndrome and biological plausibility of disease-specific probiotic intervention: a translational study.Journal of translational medicine · 2026Article
- Neonatal enteral antibiotics reduce gut inflammation and delay systemic immune development in preterm pigs.Pediatric research · 2026Article
- Early empiric antibiotic exposure affects gut microbiota development of very preterm infants.Pediatric research · 2026Article
- Early-Life Gut Microbiota: Education of the Immune System and Links to Autoimmune Diseases.Microorganisms · 2026Review
- Risk factors for necrotizing enterocolitis in preterm infants: a 1:1 matched case-control study.Frontiers in pediatrics · 2026Article
- Sex differences in the blood metabolome of extremely preterm infants: a pilot study on the impact of antibiotic therapy.Biology of sex differences · 2025Article
- Perinatal antibiotic exposure and risk of childhood infections: a retrospective cohort study.Lancet regional health. Americas · 2025Article
- Early antibiotic exposure and the risk of necrotizing enterocolitis in preterm neonates: insights from a large multicenter cohort in China.Pediatric research · 2025Article
- Sulfated dietary fiber protects gut microbiota from antibiotics.Microbiome · 2025Article
- Associations between antibiotic exposure intensity, intestinal microbiome perturbations, and outcomes in premature neonates with bacteremia.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Dysbiotic Microbiota in Necrotizing Enterocolitis: Insights into Pathogenesis, Treatment, and Prevention.Gastroenterology clinics of North America · 2025Review
- Altered heme metabolism and hemoglobin concentration due to empirical antibiotics-induced gut dysbiosis in preterm infants.Computational and structural biotechnology journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Antibiotic use in neonates can have detrimental effects on the developing gut microbiome, increasing the risk of morbidity. A majority of preterm neonates receive antibiotics after birth without clear evidence to guide this practice. Here microbiome, metabolomic, and immune marker results from the routine early antibiotic use in symptomatic preterm Neonates (REASON) study are presented. The REASON study is the first trial to randomize symptomatic preterm neonates to receive or not receive antibiotics in the first 48 h after birth. Using 16S rRNA sequencing of stool samples collected longitudinally for 91 neonates, the effect of such antibiotic use on microbiome diversity is assessed. The results illustrate that type of nutrition shapes the early infant gut microbiome. By integrating data for the gut microbiome, stool metabolites, stool immune markers, and inferred metabolic pathways, an association was discovered between Veillonella and the neurotransmitter gamma-aminobutyric acid (GABA). These results suggest early antibiotic use may impact the gut-brain axis with the potential for consequences in early life development, a finding that needs to be validated in a larger cohort.Trial Registration This project is registered at clinicaltrials.gov under the name "Antibiotic 'Dysbiosis' in Preterm Infants" with trial number NCT02784821.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.