ArticleScientific reports2021
Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- IL-1β as an important mediator of macrophage-chondrocyte crosstalk in pararamosis (rainforest arthritis).Frontiers in immunology · 2026Article
- Investigating the impact of Premolis semirufa caterpillar bristle toxins on human chondrocyte activation and inflammation.PLoS neglected tropical diseases · 2025Article
- Complement-mediated and direct activation of human neutrophils induced byFrontiers in immunology · 2025Article
- Pararamosis, a Neglected Tropical Disease Induced byInternational journal of molecular sciences · 2024Article
- Complement System Inhibition Modulates the Inflammation Induced by the Venom ofInternational journal of molecular sciences · 2022Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and cartilage degeneration, leading to joint stiffness. Aiming to determine the bristle components that could be responsible for this peculiar envenomation, in this work we have examined the toxin composition of the caterpillar bristles extract and compared it with the differentially expressed genes (DEGs) in synovial biopsies of patients affected with rheumatoid arthritis (RA) and osteoarthritis (OA). Among the proteins identified, 129 presented an average of 63% homology with human proteins and shared important conserved domains. Among the human homologous proteins, we identified seven DEGs upregulated in synovial biopsies from RA or OA patients using meta-analysis. This approach allowed us to suggest possible toxins from the pararama bristles that could be responsible for starting the joint disease observed in pararamosis. Moreover, the study of pararamosis, in turn, may lead to the discovery of specific pharmacological targets related to the early stages of articular diseases.
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Registered trials
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