ArticleTranslational psychiatry2021
Brain dynamics: the temporal variability of connectivity, and differences in schizophrenia and ADHD.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Functional connectivity signatures of NMDAR dysfunction in schizophrenia-integrating findings from imaging genetics and pharmaco-fMRI.Translational psychiatry · 2023Trial
- Altered temporal variability-based functional reorganization of brain networks predicts motor outcome after stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- Alterations in Multidimensional Functional Connectivity Architecture in Preschool Children with Autism Spectrum Disorder.Brain sciences · 2026Article
- Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2025Article
- Depression links to unstable resting-state brain dynamics: insights from hidden markov models and functional network variability.Psychological medicine · 2025Article
- Cerebellar and subcortical interplay in cognitive dysmetria: functional network signatures associate with symptom and trait assessments across schizophrenia, bipolar II, and ADHD patients.Brain imaging and behavior · 2025Article
- Histaminergic Innervation of the Ventral Anterior Thalamic Nucleus Alleviates Motor Deficits in a 6-OHDA-Induced Rat Model of Parkinson's Disease.Neuroscience bulletin · 2025Article
- Theta and alpha connectivity in children with autism spectrum disorder.Brain communications · 2025Article
- Modulation of habenular and nucleus accumbens functional connectivity by ketamine in major depression.Brain and behavior · 2024Article
- The Constrained Disorder Principle May Account for Consciousness.Brain sciences · 2024Review
- Associations between ADHD and risk of six psychiatric disorders: a Mendelian randomization study.BMC psychiatry · 2024Article
- Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study.Biological psychiatry global open science · 2023Article
- Characterizing Topological Properties of Brain Functional Networks Using Multi-Threshold Derivative for End-Stage Renal Disease with Mild Cognitive Impairment.Brain sciences · 2023Article
- A systematic approach to brain dynamics: cognitive evolution theory of consciousness.Cognitive neurodynamics · 2023Article
- Flicker light stimulation induces thalamocortical hyperconnectivity with LGN and higher-order thalamic nuclei.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Modern views of machine learning for precision psychiatry.Patterns (New York, N.Y.) · 2022Review
- Altered neural flexibility in children with attention-deficit/hyperactivity disorder.Molecular psychiatry · 2022Article
- Dynamic Functional Connectivity of Emotion Processing in Beta Band with Naturalistic Emotion Stimuli.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
We describe advances in the understanding of brain dynamics that are important for understanding the operation of the cerebral cortex in health and disease. In data from 1017 participants from the Human Connectome Project, we show that early visual and connected areas have low temporal variability of their functional connectivity. We show that a low temporal variability of the connectivity of cortical areas is related to high mean functional connectivity between those areas, and provide an account of how these dynamics arise. We then investigate how these concepts help to understand brain dynamics in mental disorders. We find that in both first episode and long-term schizophrenia, reduced functional connectivity of early visual and related temporal cortex areas is associated with increased temporal variability of the functional connectivity, consistent with decreased stability of attractor networks related to sensory processing. In ADHD, we find these functional connectivities are increased and their temporal variability is decreased, and relate this to increased engagement with visual sensory input as manifest in high screen time usage in ADHD. We further show that these differences in the dynamics of the cortex in schizophrenia, and ADHD can be related to differences in the functional connectivity of the specific sensory vs. association thalamic nuclei. These discoveries help to advance our understanding of cortical operation in health, and in some mental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.