ArticleScience (New York, N.Y.)2021
Developmental cell programs are co-opted in inflammatory skin disease.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 319 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
319citing papers in PubMed, 3 pooled it
32.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
319 citing papers in PubMed, 3 syntheses or guidelines pooled it, 490 citations in OpenAlex.
- A multi-dataset single-cell meta-analysis of human keloid skin across Asian, Black and White populations reveals endothelial and mesenchymal programs linked to ethnic disparities.Frontiers in medicine · 2026Pooled it
- Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis.Nature communications · 2025Pooled it
- New hope for the treatment of recurrent and refractory psoriasis: NK cell immunotherapy-A scientometric analysis.Frontiers in immunology · 2025Pooled it
- Hmga2-dependent cAMP signaling drives UVB-induced melanocyte stem cell activation.The Journal of investigative dermatology · 2026Article
- A single-cell RNA-seq dataset characterizing cellular diversity in healthy equine skin.Scientific data · 2026Article
- In vitro differentiation and phenotypic profiling of Langerhans cell subsets derived from human peripheral blood monocytes.Immunologic research · 2026Article
- Immune-stromal dysregulation and senescence in chronic spontaneous urticaria.The journal of allergy and clinical immunology. Global · 2026Article
- Stepwise multi-scale reconstruction of cell spatial organization from single-cell RNA sequencing data with Cell2space.Briefings in bioinformatics · 2026Article
- Interleukin 4-driven loss of stromal LIF signaling affects immune responses and cell-cell adhesion in atopic dermatitis.iScience · 2026Article
- CoxFormer enables spatial omics inference with multimodal generative modeling.Nature communications · 2026Article
- Prenatal PMNature communications · 2026Article
- Atopic Dermatitis Beyond the Skin Barrier: Precision Medicine Approaches to Immunological Profiling and Therapeutic Innovation.International journal of molecular sciences · 2026Review
- Macrophages in embryonic development.Nature reviews. Immunology · 2026Review
- Article
- Skin-resident Langerhans cells drive neuropathic pain via chemokine-dependent neuron-immune communication.The Journal of clinical investigation · 2026Article
- Article
- Immunological differences in atopic dermatitis across age groups: insights from single-cell multi-omics.Journal of translational medicine · 2026Article
- HNRNPU and architectural lncRNAs as nuclear tethers of epithelial state stability.EMBO molecular medicine · 2026Review
- Article
- Identification of Pathogenic Variants inInternational journal of molecular sciences · 2026Article
259 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
49 authors at 11 institutions in 3 countries.
Gary Reynolds *Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-8142-8708
Peter Vegh *Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-0133-3240
James Fletcher *Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0001-9610-1858
Elizabeth F M Poyner *Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-0443-9980
Emily StephensonBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-4244-4019
Issac GohBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-6397-3518
Rachel A BottingBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0001-9595-4605
Ni HuangWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID https://orcid.org/0000-0001-8849-038X
Bayanne OlabiBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-4786-7838
Anna DuboisBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-5248-3687
David DixonBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-5904-9074
Kile GreenBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-4777-5458
Daniel MaunderBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Justin EngelbertBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Mirjana EfremovaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Krzysztof PolańskiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID https://orcid.org/0000-0002-2586-9576
Laura JardineBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Claire JonesBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-4580-6564
Thomas NessBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0003-3587-2098
Dave HorsfallBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-8086-812X
Jim McGrathBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0001-6703-4473
Christopher CareyBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-4293-3920
Dorin-Mirel PopescuBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Simone WebbBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0003-3058-8952
Xiao-Nong WangBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0003-1282-8799
Ben SayerBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-1524-728X
Jong-Eun ParkWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID https://orcid.org/0000-0002-1687-2423
Victor A NegriCentre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital Campus, London SE1 9RT, UK.ORCID https://orcid.org/0000-0002-9188-1370
Daria BelokhvostovaCentre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital Campus, London SE1 9RT, UK.ORCID https://orcid.org/0000-0001-9980-0515
Magnus D LynchCentre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital Campus, London SE1 9RT, UK.
David McDonaldBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-2410-9364
Andrew FilbyBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0001-9078-4360
Tzachi HagaiShmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.ORCID https://orcid.org/0000-0002-4575-6624
Kerstin B MeyerWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID https://orcid.org/0000-0001-5906-1498
Akhtar HusainDepartment of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.ORCID https://orcid.org/0000-0001-8563-3859
Jonathan CoxheadBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Roser Vento-TormoWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID https://orcid.org/0000-0002-9870-8474
Sam BehjatiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID https://orcid.org/0000-0002-6600-7665
Steven LisgoBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0001-5186-3971
Alexandra-Chloé VillaniBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0001-7461-0408
Jaume BacarditSchool of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, UK.ORCID https://orcid.org/0000-0002-2692-7205
Philip H JonesWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID https://orcid.org/0000-0002-5904-795X
Edel A O'TooleCentre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK.
Graham S OggMRC Human Immunology Unit, Oxford Biomedical Research Centre, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-3097-045X
Neil RajanBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-5850-5680
Nick J ReynoldsDepartment of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.ORCID https://orcid.org/0000-0002-6484-825X
Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. st9@sanger.ac.uk fiona.watt@kcl.ac.uk m.a.haniffa@newcastle.ac.uk.ORCID https://orcid.org/0000-0002-6294-6366
Fiona M WattCentre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital Campus, London SE1 9RT, UK. st9@sanger.ac.uk fiona.watt@kcl.ac.uk m.a.haniffa@newcastle.ac.uk.ORCID https://orcid.org/0000-0001-9151-5154
Muzlifah HaniffaBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. st9@sanger.ac.uk fiona.watt@kcl.ac.uk m.a.haniffa@newcastle.ac.uk.ORCID https://orcid.org/0000-0002-3927-2084
Newcastle University · GBWellcome Sanger Institute · GBGuy's Hospital · GBNIHR Newcastle Biomedical Research Centre · GBUniversity of Cambridge · GBBroad Institute · USMRC Human Immunology Unit · GBNHS Lothian · GBQueen Mary University of London · GBRoyal Victoria Infirmary · GBTel Aviv University · IL
Funding
Medical Research Council G116/150Medical Research Council MC_EX_MR/R022550/1Medical Research Council MC_U137881017Medical Research Council MC_UU_00008/5Medical Research Council MC_UU_12010/5Medical Research Council MC_UU_12022/3Medical Research Council MR/R006237/1Wellcome Trust 088555Wellcome Trust 221052
Abstract
The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis. We leveraged these datasets to compare cell states across development, homeostasis, and disease. Our analysis revealed an enrichment of innate immune cells in skin during the first trimester and clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. We uncovered and validated in situ a reemergence of prenatal vascular endothelial cell and macrophage cellular programs in atopic dermatitis and psoriasis lesional skin. These data illustrate the dynamism of cutaneous immunity and provide opportunities for targeting pathological developmental programs in inflammatory skin diseases.
Indexed as
AnimalsAtlases as TopicCell MovementDatasets as TopicDendritic CellsDermatitis, AtopicDermatologic AgentsHumansImmunity, InnateMethotrexateMicePhagocytesPsoriasisSingle-Cell AnalysisSkinT-LymphocytesDermatologic AgentsMethotrexate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.