ArticleScience (New York, N.Y.)2021
Noncanonical scaffolding of G
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 112 citations in OpenAlex.
- Atomic, structural and molecular insights into GPCR ligand binding and signalling.Nature reviews. Molecular cell biology · 2026Review
- Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins.Nature communications · 2026Article
- Inhibitory probes for spatiotemporal analysis of GαNature chemical biology · 2026Article
- Small-molecule modulation of β-arrestins.Nature · 2026Article
- β-arrestin recruitment facilitates a direct association with G proteins.Nature communications · 2026Article
- Article
- Structural dynamics of kappa opioid receptor interactions with β-arrestin 1.Nature communications · 2026Article
- Location-biased β-arrestin conformations direct GPCR signaling.Science signaling · 2026Article
- Functional and structural insights into interactions between β-Arrestin 1 and Gαs or Gαi1.Nature communications · 2026Article
- Patchouli alcohol triggers autophagic cell death in non-small cell lung cancer cells through targeting GNAI1 to dissociate the GNAI1/ARRB1 complex.International journal of biological sciences · 2026Article
- Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation.Nature communications · 2025Article
- Septin organization is regulated by the Gpa1 ubiquitination domain and endocytic machinery during the yeast pheromone response.Molecular biology of the cell · 2025Article
- Astrocyte FGF7/FGFR2 autocrine signaling mediates neuroinflammation and promotes MPTP-induced degeneration of dopaminergic neurons.Acta pharmaceutica Sinica. B · 2025Article
- Article
- Luciferase complementation for cellular assays beyond protein-protein interactions.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- Intersection of GPCR trafficking and cAMP signaling at endomembranes.The Journal of cell biology · 2025Review
- Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration.eLife · 2025Article
- β-arrestin 1 and integrin-linked kinase interact in epidermal keratinocytes and regulate cell motility.Tissue barriers · 2025Article
- VPS26 Moonlights as a β-Arrestin-like Adapter for a 7-Transmembrane RGS Protein inBiochemistry · 2024Article
- Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors.Nature reviews. Nephrology · 2024Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Jeffrey S Smith *Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0003-2840-2899
Thomas F Pack *Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0002-1240-8324
Asuka InoueDepartment of Pharmaceutical Sciences, Tohoku University, Japan.ORCID https://orcid.org/0000-0003-0805-4049
Claudia LeeDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0003-1952-3859
Kevin ZhengDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0002-1437-2820
Issac ChoiDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Dylan S EigerDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0001-9572-6282
Anmol WarmanDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0001-5564-6747
Xinyu XiongDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0002-9803-8503
Zhiyuan MaDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0002-0381-7804
Gayathri ViswanathanDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0001-7395-919X
Ian M LevitanDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Lauren K RochelleDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0002-0669-1362
Dean P StausDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Joshua C SnyderDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0002-9787-3371
Alem W KahsaiDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0001-9272-4484
Marc G CaronDepartment of Medicine, Duke University Medical Center, Durham, NC 27710, USA.ORCID https://orcid.org/0000-0003-0172-2710
Sudarshan RajagopalDepartment of Medicine, Duke University Medical Center, Durham, NC 27710, USA. sudarshan.rajagopal@duke.edu.ORCID https://orcid.org/0000-0002-3443-5040
Duke Medical Center · USDuke University · USTohoku University · JP
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2MMedical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6MAkt/GSK-3 Signaling Cascade and the Actions of DopamineR37MH073853 · NIMH · DUKE UNIVERSITY · PI CARON, MARC G. · 2011 to 2020
$6.4MBiasing CXCR3 Signaling to Modulate the Inflammatory ResponseR01GM122798 · NIGMS · DUKE UNIVERSITY · PI RAJAGOPAL, SUDARSHAN · 2017 to 2025
$3.2MSupplemental Funds for K22 Establishing the molecular and cellular mechanisms of Lgr5 signaling for controlling cancer stem cell behaviorK22CA212058 · NCI · DUKE UNIVERSITY · PI SNYDER, JOSHUA CLAIR · 2017 to 2020
$622kNoncanonical Receptor Signaling in Pulmonary Arterial HypertensionK08HL114643 · NHLBI · DUKE UNIVERSITY · PI RAJAGOPAL, SUDARSHAN K · 2013 to 2017
$607kDissecting the Distinct Arrestin Signaling Capabilities of the Short and Long Dopamine D2 Receptors as a Paradigm for Psychostimulant Addiction TreatmentF31DA041160 · NIDA · DUKE UNIVERSITY · PI PACK, THOMAS FRANKLIN · 2016 to 2017
$67kNCI NIH HHS K22 CA212058NHLBI NIH HHS K08 HL114643NIDA NIH HHS F31 DA041160NIGMS NIH HHS R01 GM122798NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM145449NIMH NIH HHS R37 MH073853
Abstract
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) are common drug targets and canonically couple to specific G
Indexed as
beta-ArrestinsBioluminescence Resonance Energy Transfer TechniquesCell MovementExtracellular Signal-Regulated MAP KinasesGTP-Binding Protein alpha Subunits, Gi-GoHEK293 CellsHumansReceptors, G-Protein-CoupledSignal Transductionbeta-ArrestinsExtracellular Signal-Regulated MAP KinasesGTP-Binding Protein alpha Subunits, Gi-GoReceptors, G-Protein-Coupled
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.