Evidence map›Paper›PMID 33479118›Full record

ArticleScience (New York, N.Y.)2021

Model-informed COVID-19 vaccine prioritization strategies by age and serostatus.

Kate M Bubar, Kyle Reinholt, Stephen M Kissler, Marc Lipsitch, Sarah Cobey, Yonatan H Grad, Daniel B Larremore

Registry-linked trialAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04944095 (Serology Testing), which is not on this map. Cited by 390 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
390citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04944095 unknown statusnot on this map

Serology Testing (Antibody Levels) With Time Following SARS-CoV-2 (Covid-19) Vaccinations in Residents of Nursing, Extended Care, and Over-55 Communities

TypeobservationalSponsorDr. Sidney J. StohsRan2021 to 2024Enrolled10,000ConditionsCovid-19, Subjects Vaccinated Against Covid-19ArmsChange in SARS-CoV-2 Antibody Levels
3 · Its place in the literature

Who cites it

390 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Incorporating Social Determinants of Health in Infectious Disease Models: A Systematic Review of Guidelines.Medical decision making : an international journal of the Society for Medical Decision Making · 2024
    Pooled it
  3. Pooled it
  4. Inequality in the distribution of Covid-19 vaccine: a systematic review.International journal for equity in health · 2022
    Pooled it
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330 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kate M BubarDepartment of Applied Mathematics, University of Colorado Boulder, Boulder, CO 80309, USA. kate.bubar@colorado.edu daniel.larremore@colorado.edu.ORCID https://orcid.org/0000-0002-1876-3132
Kyle ReinholtDepartment of Computer Science, University of Colorado Boulder, Boulder, CO 80309, USA.
Stephen M KisslerDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Marc LipsitchDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0003-1504-9213
Sarah CobeyDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0001-5298-8979
Yonatan H GradDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0001-5646-1314
Daniel B LarremoreDepartment of Computer Science, University of Colorado Boulder, Boulder, CO 80309, USA. kate.bubar@colorado.edu daniel.larremore@colorado.edu.ORCID https://orcid.org/0000-0001-5273-5234

Funding

MIDAS Coordination CenterU24GM132013 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOCHHEISER, HARRY S · 2019 to 2023
$8.1M
Casual, Statistical and Mathematical Modeling with Serologic DataU01CA261277 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANAGE, WILLIAM, LIPSITCH, MARC · 2020 to 2023
$2.8M
NCI NIH HHS U01 CA261277NIGMS NIH HHS U24 GM132013Wellcome Trust
6 · The paper itself

Abstract

Limited initial supply of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine raises the question of how to prioritize available doses. We used a mathematical model to compare five age-stratified prioritization strategies. A highly effective transmission-blocking vaccine prioritized to adults ages 20 to 49 years minimized cumulative incidence, but mortality and years of life lost were minimized in most scenarios when the vaccine was prioritized to adults greater than 60 years old. Use of individual-level serological tests to redirect doses to seronegative individuals improved the marginal impact of each dose while potentially reducing existing inequities in COVID-19 impact. Although maximum impact prioritization strategies were broadly consistent across countries, transmission rates, vaccination rollout speeds, and estimates of naturally acquired immunity, this framework can be used to compare impacts of prioritization strategies across contexts.

Indexed as

Health PrioritiesMass VaccinationAdolescentAdultAgedAge FactorsAntibodies, ViralChildCOVID-19COVID-19 VaccinesHumansImmunogenicity, VaccineMiddle AgedModels, TheoreticalSARS-CoV-2Seroepidemiologic StudiesAntibodies, ViralCOVID-19 Vaccines

Identifiers

PMID33479118
PMCPMC7963218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.