ReviewClinical medicine (London, England)2021
The challenges of chronic pain and fatigue.
Review in Clinical medicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Chronic pain and fatigue in multiple osteochondroma and Ollier disease, a systematic review.BMC musculoskeletal disorders · 2026Pooled it
- Examining the psychometric properties of brief screening measures of depression and anxiety in chronic pain: The Patient Health Questionnaire 2-item and Generalized Anxiety Disorder 2-item.Pain practice : the official journal of World Institute of Pain · 2022Pooled it
- Mental- and physical-health comorbidity are strongly associated in idiopathic inflammatory myopathies: a multinational cross-sectional e-survey.Rheumatology international · 2026Article
- Unravelling the diversity of pacing behaviours in adults with chronic conditions: a cross-sectional study.BMJ open · 2026Observational
- Article
- Rethinking coping in chronic pain: a systematic review and dynamic interaction model of coping.Pain reports · 2026Review
- Testing culturally relevant EQ-5D-5L bolt-ons for the Chinese general population: first quantitative phase of a mixed methods study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Risk Factors for Fatigue in Adults Receiving Maintenance Hemodialysis Who Have Chronic Pain: A Secondary Analysis of the HOPE Consortium Trial.Kidney medicine · 2026Article
- Understanding the Barriers and Facilitators of Implementing a Controlled Substance Safety Committee in a Primary Care Practice.Journal of the American Board of Family Medicine : JABFM · 2025Article
- Exploring patient experiences of pain fatigue and physical activity in syndromic heritable thoracic aortic disease using mixed methods.Scientific reports · 2025Article
- Combined Proxies for Heart Rate Variability as a Global Tool to Assess and Monitor Autonomic Dysregulation in Fibromyalgia and Disease-Related Impairments.Sensors (Basel, Switzerland) · 2025Observational
- A Study on the Association Between Risk Factors and Psychosocial Factors of Non-Cardiac Chest Pain (NCCP) in Adults Aged 40 and Above Based on 2013-2018 US NHANES Data.Journal of pain research · 2025Article
- Towards vitality: a longitudinal pilot study with a cognitive bias modification e-health intervention (VitalMe) to reduce fatigue in patients with chronic kidney disease.Health psychology and behavioral medicine · 2025Article
- The efficacy of a clustered group-based acceptance and commitment therapy for patients with chronic pain - a randomized controlled semi-crossover trial.Canadian journal of pain = Revue canadienne de la douleur · 2025Article
- Inflammation is associated with pain and fatigue in older adults.Brain, behavior, & immunity - health · 2024Article
- The role of fatigue in patients with complex regional pain syndrome.Journal of neurology · 2024Article
- Nordic Walking as a Non-Pharmacological Intervention for Chronic Pain and Fatigue: Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- Is joint hypermobility linked to self-reported non-recovery from COVID-19? Case-control evidence from the British COVID Symptom Study Biobank.BMJ public health · 2024Article
- Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men.The journal of pain · 2024Article
- Prognostic subgroups of chronic pain patients using latent variable mixture modeling within a supervised machine learning framework.Scientific reports · 2024Article
Corrections and comments
- Commented on by
- Commented on byResponse.2021
Authors and funding
2 authors.
Funding
Abstract
In this review, we explore the challenges of chronic pain and fatigue in clinical practice. Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the 'clinical problem'. We explore commonly associated symptoms and possible pathological associations, including variant connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation, dysregulated inflammatory and interoceptive processes, which may inform treatment targets. We suggest a multidisciplinary management approach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.