ArticleDiabetes2021
The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium.
Erratum issued Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00722397 (Studies to Treat Or Prevent Pediatric Type 2 Diabetes), which is not on this map. Cited by 50 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 5 pooled it
10.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Genetics Study
Who cites it
50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Depression comorbidity in children and adolescents with type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- ISPAD Clinical Practice Consensus Guidelines 2024: Type 2 Diabetes in Children and Adolescents.Hormone research in paediatrics · 2024Guideline
- Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies.Bioinformatics (Oxford, England) · 2023Pooled it
- Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.Diabetes care · 2023Pooled it
- Risk factors of early-onset type 2 diabetes: A systematic review and meta-analysis.Diabetes & vascular disease researchPooled it
- Applying Artificial Intelligence to Childhood Obesity: T2DM and MASLD Risk Predictive Models.Diagnostics (Basel, Switzerland) · 2026Review
- Type 2 diabetes prevention across the life course.Nature medicine · 2026Review
- The Potential Physiologic Mechanisms by Which Early-Life Nutrition May Influence Type 2 Diabetes Pathophysiology in Humans.Annual review of nutrition · 2026Review
- Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program.Diabetes · 2025Article
- Comparative risk of end-stage renal disease, myocardial infarction and stroke in young and older onset diabetes in UK Biobank.Scientific reports · 2025Article
- Review
- In Utero Exposure to Maternal Hyperglycemia and Offspring Type 2 Diabetes Genetic Risk Score Are Independently Associated With Risk of Impaired Glucose Tolerance in Youth.Diabetes care · 2025Article
- Clinical and Genetic Characteristics of Patients with Early-Onset Diabetes Involving at Least Two Consecutive Generations: Whole-Exome Sequencing in Probands from 25 Pedigrees.Current medical science · 2025Article
- Youth-Onset Type 2 Diabetes: What We've Learned From Key Youth-Onset Type 2 Diabetes Studies, What We Still Don't Know, and Why It Is Important.Diabetes care · 2025Review
- Young-onset type 2 diabetes-Epidemiology, pathophysiology, and management.Journal of diabetes investigation · 2025Review
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular-kidney complications.Diabetologia · 2025Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- Enhanced adaptive permutation test with negative binomial distribution in genome-wide omics datasets.Genes & genomics · 2025Article
- Latent autoimmune diabetes in youth.Frontiers in immunology · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 13 institutions in 1 country.
Shylaja SrinivasanDivision of Pediatric Endocrinology, University of California, San Francisco, San Francisco, CA.
Ling ChenCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.
Jennifer ToddDivision of Pediatric Endocrinology, University of Vermont, Burlington, VT.
Jasmin DiversNYU Langone Health, New York, NY.
Samuel GiddingGenomic Medicine Institute, Geisinger, Danville, PA.
Steven ChernausekPediatric Diabetes and Endocrinology Section, University of Oklahoma College of Medicine, Oklahoma City, OK.ORCID 0000-0002-9927-4460
Rose A Gubitosi-KlugPediatric Endocrinology, Diabetes, and Metabolism, Case Western Reserve University and Rainbow Babies and Children's Hospital, Cleveland, OH.ORCID 0000-0002-7376-6870
Megan M KelseyPediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO.ORCID 0000-0002-0755-1951
Rachana ShahPediatric Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA.
Mary Helen BlackJanssen Pharmaceuticals, Spring House, PA.
Lynne E WagenknechtPublic Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
Alisa ManningCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.
Jason FlannickProgram in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA.
Giuseppina ImperatoreCenters for Disease Control and Prevention, Atlanta, GA.
Josep M MercaderCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.
Dana DabeleaDepartment of Epidemiology, University of Colorado School of Public Health, Aurora, CO.ORCID 0000-0001-9514-8929
Jose C FlorezORCID 0000-0002-1730-9325
ProDiGY Consortium
Broad Institute · USCenters for Disease Control and Prevention · USChildren's Hospital of Philadelphia · USColorado School of Public Health · USJanssen (United States) · USMassachusetts General Hospital · USNYU Langone Health · USOklahoma City University · USRainbow Babies & Children's Hospital · USUniversity of California, San Francisco · USUniversity of Colorado Denver · USUniversity of Vermont · USWake Forest University · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MTreatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) StudyU01DK061230 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BRAFFETT, BARBARA HALINA, ZEITLER, PHILIP S. · 2001 to 2019
$231.8MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MHARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4MZOPOLRESTAT IN NORMOTENSIVE, TYPE 1 DIA WITH INCIPIENT NEPHROPATHYM01RR000043 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAIA, JOHN A · 1985 to 2010
$76.4MUNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9MINSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3MYALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7MInstitute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4MWashington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
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Abstract
The prevalence of type 2 diabetes in youth has increased substantially, yet the genetic underpinnings remain largely unexplored. To identify genetic variants predisposing to youth-onset type 2 diabetes, we formed ProDiGY, a multiethnic collaboration of three studies (TODAY, SEARCH, and T2D-GENES) with 3,006 youth case subjects with type 2 diabetes (mean age 15.1 ± 2.9 years) and 6,061 diabetes-free adult control subjects (mean age 54.2 ± 12.4 years). After stratifying by principal component-clustered ethnicity, we performed association analyses on ∼10 million imputed variants using a generalized linear mixed model incorporating a genetic relationship matrix to account for population structure and adjusting for sex. We identified seven genome-wide significant loci, including the novel locus rs10992863 in
Indexed as
AdultDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseGenome-Wide Association StudyHomeodomain ProteinsHumansKCNQ1 Potassium ChannelMiddle AgedPolymorphism, Single NucleotideReceptor, Melanocortin, Type 4Homeodomain ProteinsKCNQ1 Potassium ChannelKCNQ1 protein, humanMC4R protein, humanPHF2 protein, humanReceptor, Melanocortin, Type 4
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT00722397ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.