ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Overlooked Tertiary Sulci Serve as a Meso-Scale Link between Microstructural and Functional Properties of Human Lateral Prefrontal Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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47 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Accurate localization and coactivation profiles of the frontal eye field and inferior frontal junction: an ALE and MACM fMRI meta-analysis.Brain structure & function · 2023Pooled it
- Sulcal pleating captures functional boundaries in human visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Detailed Examination of the Sulci and Gyri Surrounding Broca's Area: A Comparative Morphological Study of Japanese and North American Populations.Neurologia medico-chirurgica · 2026Article
- Gyral Crowns Contribute to the Cortical Infrastructure of Human Face Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Variable Presence of an Evolutionarily New Brain Structure Is Related to Trait Impulsivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Anchoring Functional Connectivity to Individual Sulcal Morphology Yields Insights in a Pediatric Study of Reasoning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Burst of gyrification in the human brain after birth.Communications biology · 2025Article
- Layer-Dependent Effect of Aβ-Pathology on Cortical Microstructure With Ex Vivo Human Brain Diffusion MRI at 7 Tesla.Human brain mapping · 2025Article
- Leveraging Input-Level Feature Deformation With Guided-Attention for Sulcal Labeling.IEEE transactions on medical imaging · 2025Article
- Anchoring functional connectivity to individual sulcal morphology yields insights in a pediatric study of reasoning.bioRxiv : the preprint server for biology · 2025Article
- A Self-supervised Deep Learning Model for Diagonal Sulcus Detection with Limited Labeled Data.Neuroinformatics · 2025Article
- Emotion-related impulsivity is related to orbitofrontal cortical sulcation.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Defining putative tertiary sulci in lateral prefrontal cortex in chimpanzees using human predictions.Brain structure & function · 2024Article
- Variable Presence of an Evolutionarily New Brain Structure is Related to Trait Impulsivity.bioRxiv : the preprint server for biology · 2024Article
- An MRI Study of Morphology, Asymmetry, and Sex Differences of Inferior Precentral Sulcus.Brain topography · 2024Article
- Unique longitudinal contributions of sulcal interruptions to reading acquisition in children.bioRxiv : the preprint server for biology · 2024Article
- Morphological patterns and spatial probability maps of the inferior frontal sulcus in the human brain.Human brain mapping · 2024Article
- Information-based TMS to mid-lateral prefrontal cortex disrupts action goals during emotional processing.Nature communications · 2024Article
- Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights.bioRxiv : the preprint server for biology · 2024Article
- Defining Overlooked Structures Reveals New Associations between the Cortex and Cognition in Aging and Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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5 authors at 1 institution in 1 country.
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Abstract
Understanding the relationship between neuroanatomy and function in portions of cortex that perform functions largely specific to humans such as lateral prefrontal cortex (LPFC) is of major interest in systems and cognitive neuroscience. When considering neuroanatomical-functional relationships in LPFC, shallow indentations in cortex known as tertiary sulci have been largely unexplored. Here, by implementing a multimodal approach and manually defining 936 neuroanatomical structures in 72 hemispheres (in both males and females), we show that a subset of these overlooked tertiary sulci serve as a meso-scale link between microstructural (myelin content) and functional (network connectivity) properties of human LPFC in individual participants. For example, the posterior middle frontal sulcus (pmfs) is a tertiary sulcus with three components that differ in their myelin content, resting-state connectivity profiles, and engagement across meta-analyses of 83 cognitive tasks. Further, generating microstructural profiles of myelin content across cortical depths for each pmfs component and the surrounding middle frontal gyrus (MFG) shows that both gyral and sulcal components of the MFG have greater myelin content in deeper compared with superficial layers and that the myelin content in superficial layers of the gyral components is greater than sulcal components. These findings support a classic, yet largely unconsidered theory that tertiary sulci may serve as landmarks in association cortices, as well as a modern cognitive neuroscience theory proposing a functional hierarchy in LPFC. As there is a growing need for computational tools that automatically define tertiary sulci throughout cortex, we share pmfs probabilistic sulcal maps with the field.
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